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Quality of life after radical prostatectomy or watchful waiting.
The assignment of patients to watchful waiting or radical prostatectomy entails different risks of erectile dysfunction, urinary leakage, and urinary obstruction, but on average, the choice has little if any influence on well-being or the subjective quality of life after a mean follow-up of four years. Expand
A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer.
In this randomized trial, radical prostatectomy significantly reduced disease-specific mortality, but there was no significant difference between surgery and watchful waiting in terms of overall survival. Expand
The sextant protocol for ultrasound-guided core biopsies of the prostate underestimates the presence of cancer.
The standard sextant biopsy protocol leaves 15% of cancers undetected compared with results obtained from a more extensive biopsy procedure, but a major concern is that the clinical importance of cancers detected by multiple biopsies needs to be evaluated. Expand
5-year followup of a randomized prospective study comparing mitomycin C and bacillus Calmette-Guerin in patients with superficial bladder carcinoma. Swedish-Norwegian Bladder Cancer Study Group.
Therapy with BCG was superior to mitomycin C for recurrence prophylaxis but no difference was found for progression and survival, which was most pronounced for stage Tis disease. Expand
A systematic overview of radiation therapy effects in prostate cancer
There are no randomized studies that compare the outcome of surgery with either external beam radiotherapy or brachytherapy for patients with clinically localized low-risk prostate cancer, and there is fairly strong evidence that patients with localized, intermediate risk, and high risk disease, i.e. patients normally not suited for surgery, benefit from higher than conventional total dose of radiation therapy. Expand
[Crohn's disease and pregnancy].
Radical prostatectomy versus watchful waiting in early prostate cancer.
The absolute reduction in the risk of death after 10 years is small, but the reductions in the risks of metastasis and local tumor progression are substantial. Expand
Detection of cytochrome P450 mRNA transcripts in prostate samples by RT‐PCR
Background The expression of cytochrome P450 (CYP)‐dependent mono‐oxygenases in the prostate is important, as it will determine the rate of activation of potential carcinogens as well as theExpand
Messenger Ribonucleic Acid Levels of Steroid 5α-Reductase 2 in Human Prostate Predict the Enzyme Activity1
A strong association between enzyme activity at pH 5.5 and the 5α-reductase 2-specific mRNA expression when expressed on the basis of β-actin is found and is associated with a strong association with cancer risk. Expand
Impaired medullary circulation in postischemic acute renal failure.
The marked reduction in the blood flow to the renal medulla after recirculation is suggestive for a medullary ischemia, which might be responsible for the characteristic dysfunctions in acute renal failure. Expand