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PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
DNA ANALOGUES are currently being intensely investigated owing to their potential as gene-targeted drugs1–3. Furthermore, their properties and interaction with DNA and RNA could provide a betterExpand
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Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future
  • A. Ray, B. Nordén
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 June 2000
Synthetic molecules that can bind with high sequence specificity to a chosen target in a gene sequence are of major interest in medicinal and biotechnological contexts. They show promise for theExpand
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Characterization of interaction between DNA and 4',6-diamidino-2-phenylindole by optical spectroscopy.
We have examined the interaction between 4',6-diamidino-2-phenylindole (DAPI) and DNA using flow linear dichroism (LD), circular dichroism (CD), and fluorescence techniques. We show the presence ofExpand
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Linear dichroism spectroscopy of nucleic acids.
This review will consider solution studies of structure and interactions of DNA and DNA complexes using linear dichroism spectroscopy, with emphasis on the technique of orientation by flow. TheExpand
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Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique.
The binding of a mixed-sequence pentadecamer PNA (peptide nucleic acid) containing all four nucleobases to the fully complementary as well as various singly mismatched RNA and DNA oligonucleotidesExpand
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Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells.
Cell-penetrating peptides are regarded as promising vectors for intracellular delivery of large, hydrophilic molecules, but their mechanism of uptake is poorly understood. Since it has now beenExpand
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Application of a novel analysis to measure the binding of the membrane-translocating peptide penetratin to negatively charged liposomes.
The binding of penetratin, a peptide that has been found useful for cellular delivery of large hydrophilic molecules, to negatively charged vesicles was investigated. The surface charge density ofExpand
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Linear and circular dichroism of drug-nucleic acid complexes.
Publisher Summary Polarized light spectroscopy offers possibilities to quickly characterize nucleic acids and their complexes with bound proteins or drug molecules, using a relatively small amount ofExpand
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Effects of tryptophan content and backbone spacing on the uptake efficiency of cell-penetrating peptides.
Cell-penetrating peptides (CPPs) are able to traverse cellular membranes and deliver macromolecular cargo. Uptake occurs through both endocytotic and nonendocytotic pathways, but the molecularExpand
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Stimulated endocytosis in penetratin uptake: effect of arginine and lysine.
Cell-penetrating peptides can deliver macromolecular cargo into cells and show promise as vectors for intracellular drug delivery. Internalization occurs predominantly via endocytosis, but the exactExpand
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