• Publications
  • Influence
Inhibition of P2X4 Suppresses Joint Inflammation and Damage in Collagen-Induced Arthritis
TLDR
Data show that P2X4 asODN confers a therapeutic benefit on CIA, and inhibition of the NLRP1 inflammasome signaling pathway is the underlying mechanism of action. Expand
microRNAs in Spinal Cord Injury: Potential Roles and Therapeutic Implications
TLDR
The existing evidence suggests that abnormal miRNA expression following SCI contributes to the pathogenesis of SCI, and miRNAs may become potential targets for the therapy ofSCI. Expand
Biventricular Pacing Cardiac Contractility Modulation Improves Cardiac Contractile Function via Upregulating SERCA2 and miR-133 in a Rabbit Model of Congestive Heart Failure
TLDR
Biventricular pacing CCM is superior to conventional monoventricular paced CCM, producing greater improvement cardiac contractile function and greater upregulation of SERCA2 and miR-133 may account for the improvement by BVP-CCM. Expand
Microarray based analysis of gene regulation by microRNA in intervertebral disc degeneration
TLDR
A comprehensive miRNA-target gene regulatory network was constructed, which was found to be important in IDD progression, and two important microRNAs were identified that were pivotal for the development of IDD, and their target genes, CDKNAB and SMAD4. Expand
Macrophage Polarization in IL-10 Treatment of Particle-Induced Inflammation and Osteolysis.
TLDR
The effects of IL-10 in ameliorating local inflammation and osteolysis may be associated with macrophage polarization through the up-regulation of the Janus activating kinase/STAT3 signaling pathway, and the down- regulation of NF-κB and Janus activates kinase /STAT1 expression. Expand
Indirubin Increases CD4+CD25+Foxp3+ Regulatory T Cells to Prevent Immune Thrombocytopenia in Mice
TLDR
Indirubin ameliorates ITP by enhancing CD4+CD25+Foxp3+Treg cell level with preserving immunosuppressive function, and shows similar immunOSuppression on T effector cells as compared to those from control mice. Expand
A novel rabbit disc degeneration model induced by fibronectin fragment.
TLDR
Fn-f induced a progressively degenerative process in rabbit discs, which was consistent with the spontaneous degeneration in human, and seemed to be a novel and useful model for the study of disc degeneration at the molecular level. Expand
Identification of noncoding RNA expression profiles and regulatory interaction networks following traumatic spinal cord injury by sequence analysis
TLDR
Noncoding RNAs might play important roles via the competing endogenous RNA regulation pattern after TSCi and further findings arising from this study will not only expand the understanding of potential ncRNA biomarkers but also help guide therapeutic strategies for TSCI. Expand
Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy
TLDR
The characteristics of polarized astrocytes, the relationship betweenAstrocyte polarization and SCI, and new implications of reactive astrogliosis for future SCI therapies are discussed. Expand
Mismatch of AO anatomically shaped distal humeral plate with humeral shaft forward flexion angulation in adult Chinese population
TLDR
The aims of this study were to evaluate the morphological discrepancies between LCPEA and the humeral shaft FFA in Chinese cadaveric dried adult humeri and to propose a further design of pre-contoured plates to accommodate the FFA. Expand
...
1
2
3
4
5
...