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Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes
An appropriate balance between proinflammatory (Th17 and Th1) and anti-inflammatory (regulatory T cells [Tregs] and Th2) subsets of T cells is critical to maintain homeostasis and avoid inflammatoryExpand
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BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses
Histone acetylation regulates activation and repression of multiple inflammatory genes known to play critical roles in chronic inflammatory diseases. However, proteins responsible for translating theExpand
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B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
Patients with type 2 diabetes (T2D) have disease-associated changes in B-cell function, but the role these changes play in disease pathogenesis is not well established. Data herein show B cells fromExpand
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Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells, including natural killerExpand
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Toll-like receptors regulate B cell cytokine production in patients with diabetes
Aims/hypothesisUnderstanding cellular and molecular events in diabetes mellitus will identify new approaches for therapy. Immune system cells are important modulators of chronic inflammation inExpand
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PU.1 and an HLH family member contribute to the myeloid‐specific transcription of the Fc gamma RIIIA promoter.
Expression of the low‐affinity Fc receptor for IgG (murine Fc gamma RIIIA) is restricted to cells of myelomonocytic origin. We report here the promoter structure, the proximal DNA sequencesExpand
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State of the union between metabolism and the immune system in type 2 diabetes
Lymphocytes and myeloid cells (monocyte/macrophages) have important roles in multiple types of diseases characterized by unresolved inflammation. The relatively recent appreciation of obesity,Expand
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Localization of rabbit sperm acrosin during the acrosome reaction induced by immobilized zona matrix.
To better understand the loss of the acrosomal cap on the surface of the zona pellucida and the function of the equatorial-postacrosomal region after the acrosome reaction, we have constructed an inExpand
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The Igκ3′ Enhancer Is Activated by Gradients of Chromatin Accessibility and Protein Association1
The Igκ locus is recombined following initiation of a signaling cascade during the early pre-B stage of B cell development. The Ig κ3′ enhancer plays an important role in normal B cell development byExpand
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ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers
ABSTRACT A tripartite domain of the murine immunoglobulin μ heavy-chain enhancer contains the μA and μB elements that bind ETS proteins and the μE3 element that binds leucine zipper-containing basicExpand
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