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Skin immune sentinels in health and disease
TLDR
This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease and newly identified CD103+ dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens. Expand
High-Level Variability in the ORF-K1 Membrane Protein Gene at the Left End of the Kaposi’s Sarcoma-Associated Herpesvirus Genome Defines Four Major Virus Subtypes and Multiple Variants or Clades in
TLDR
Overall, it is suggested that rather than being a newly acquired human pathogen, HHV8 is an ancient human virus that is preferentially transmitted in a familial fashion and is difficult to transmit horizontally in the absence of immunosuppression. Expand
Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials
TLDR
Two studies of ixekizumab compared with placebo or etanercept to assess the safety and efficacy of specifically targeting interleukin 17A in patients with widespread moderate-to-severe psoriasis met the primary endpoints. Expand
Kaposiform Hemangioendothelioma of Infancy and Childhood: An Aggressive Neoplasm Associated with Kasabach-Merritt Syndrome and Lymphangiomatosis
TLDR
Nine distinctive, but relatively unknown, vascular tumors of infancy and childhood presenting as soft tissue masses often associated with locally aggressive disease, lymphangiomatosis and Kasabach-Merritt syndrome are reported, and treatment appears to consist of wide local excision and supportive therapy for associated symptoms. Expand
Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets.
TLDR
A purification schema that reliably yields highly purified populations of dermal dendritic cells (DDC) is provided, which have distinctive phenotypic markers and immunologic capabilities. Expand
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
TLDR
It is reported that epidermal keratinocytes in psoriatic lesions are characterized by activated Stat3, and targeting Stat3 may be potentially therapeutic in the treatment of psoriasis. Expand
Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness
TLDR
It is shown that aggressive melanoma cells secrete Nodal (a potent embryonic morphogen) and consequently can induce ectopic formation of the embryonic axis, and thus may be involved in melanoma pathogenesis. Expand
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities.
TLDR
In this review, recent progress is discussed in the areas of genetics, the immunological synapse, the untangling of the cytokine web and signaling pathways, xenotransplantation models, and the growing use of selectively targeted therapies. Expand
The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition*
TLDR
RWnt5A treatment increases Snail and vimentin expression, and decreases E-cadherin, even in the presence of dominant-negativeTCF4, suggesting that this activation is independent of Wnt/β-catenin signaling. Expand
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells.
TLDR
A novel mechanism for overcoming the apoptotic resistance of tumor cells is provided, and agents triggering NOXA induction are validated as potential selective cancer therapeutics for life-threatening malignancies such as melanoma and multiple myeloma. Expand
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