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Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells.
Glucocorticoids exert profound and diverse physiological effects on a wide range of cell types. Produced and released from the adrenal cortex in response to stress, levels of glucocorticoids are… Expand
A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines
SnowShoes-FTD, developed for fusion transcript detection in paired-end mRNA-Seq data, employs multiple steps of false positive filtering to nominate fusion transcripts with near 100% confidence.… Expand
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
- Geou-Yarh Liou, H. Doeppler, +4 authors P. Storz
- Biology, Medicine
- The Journal of cell biology
- 5 August 2013
Macrophages infiltrating the pancreas in response to inflammation induce cellular transdifferentiation by secreting cytokines that activate NF-κB signaling and matrix metalloproteinase expression.
Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor Phenotype
- Laura J. Lewis-Tuffin, F. Rodríguez, +4 authors P. Anastasiadis
- Biology, Medicine
- PloS one
- 27 October 2010
Background Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes in cadherin… Expand
Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions.
UNLABELLED Desmoplasia and an inflammatory environment are defining features of pancreatic cancer. Unclear is how pancreatic cells that undergo oncogenic transformation can cross-talk with immune… Expand
MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer.
Recognition that breast cancer is a heterogeneous disease in which each patient's tumor has specific characteristics has led to a search for biomarkers and combinations of markers (signatures) to… Expand
Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon
Suppression of colon carcinogenesis by peroxisome proliferator-activated receptor (PPAR)-γ is likely due to some effect of PPAR-γ on normal colonic epithelial cells. However, our understanding of t...
Correction: Folate Receptor-α (FOLR1) Expression and Function in Triple Negative Tumors
The tenth author’s name is spelled incorrectly. The correct name is: Alvaro Moreno-Aspitia. The Academic Editor field is missing from the published paper. The name of the Academic Editor is: Aamir… Expand
An Integrated Model of the Transcriptome of HER2-Positive Breast Cancer
Our goal in these analyses was to use genomic features from a test set of primary breast tumors to build an integrated transcriptome landscape model that makes relevant hypothetical predictions about… Expand
Toll‐like receptor 4 mediates cross‐talk between peroxisome proliferator‐activated receptor γ and nuclear factor‐κB in macrophages
The peroxisome proliferator‐activated receptor γ (PPARγ) is expressed in macrophages and plays an important role in suppressing the inflammatory response. Lipopolysaccharides (LPS), which activate… Expand