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FIB‐4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest
TLDR
For values outside 1.45‐3.25, the FIB‐4 index is a simple, accurate, and inexpensive method for assessing liver fibrosis and proved to be concordant with FibroTest results.
Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: a clinical study on 113 hepatitis C virus patients.
TLDR
SSI appears to be a fast, simple and reliable method for noninvasive liver fibrosis evaluation and comparison with FibroScan is particularly significant for mild and intermediate fibrosis levels.
Hepatitis C Virus Type 1b (II) Infection in France and Italy
TLDR
The intent of this study was to study a large group of patients to elucidate the following points: whether the pattern of distribution of HCV genotypes has been changing over time; whether severity of illness (chronic hepatitis, cirrhosis, and hepatocellular carcinoma) and response to interferon- therapy differs with theHCV genotype; and whether the level ofHCV viremia varies with severity of liver disease.
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.
TLDR
The GWA study identified several susceptibility loci for HCV-induced liver fibrosis linked to genes that regulate apoptosis; these were linked to factors involved in phagocytosis of apoptotic cells by macrophages.
Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.
TLDR
No significant correlation was found in patients infected with genotypes 1b or 3a between NS5A sequence and response to interferon alfa, andNS5A mutations do not correlate with viral load.
Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen.
TLDR
The investigation indicates that transcriptionally active HBV genomes are present in various geographic areas among patients with liver cancer who are negative for hepatitis B surface antigen, which is consistent with an etiologic role for the virus in the development of these tumors.
Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer
TLDR
The highly sensitive and specific detection of CTCs and microemboli may have clinical implications for cancer staging and outcome prediction and the feasibility of molecular studies of individual circulating tumor cells, aimed at identifying gene mutations involved in tumor invasion are shown.
Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake
TLDR
Further evidence of the importance of environmental conditions on P450 isozyme pattern, and therefore, on drug metabolizing capacity of human liver is brought, at protein level.
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