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The Traf2- and Nck-interacting Kinase as a Putative Effector of Rap2 to Regulate Actin Cytoskeleton*
Rap2 belongs to the Ras family of small GTP-binding proteins, but its specific roles in cell signaling remain unknown. In the present study, we have affinity-purified from rat brain aExpand
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Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 as a Putative Effector of Rap2 to Activate the c-Jun N-terminal Kinase*
Little is known about the specific signaling roles of Rap2, a Ras family small GTP-binding protein. In a search for novel Rap2-interacting proteins by the yeast two-hybrid system, we isolated isoformExpand
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PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector.
Rap2 belongs to the Ras family of small GTP-binding proteins, but its specific signaling role is unclear. By yeast two-hybrid screening, we have found that the Caenorhabditis elegans ortholog of Rap2Expand
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&bgr;-Myosin Heavy Chain Is Induced by Pressure Overload in a Minor Subpopulation of Smaller Mouse Cardiac Myocytes
Rationale: Induction of the fetal hypertrophic marker gene &bgr;-myosin heavy chain (&bgr;-MyHC) is a signature feature of pressure overload hypertrophy in rodents. &bgr;-MyHC is assumed present inExpand
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Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent
Rationale: It is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic receptors (ARs), &bgr;1, &bgr;2, &bgr;3, &agr;1A, and &agr;1B. The &bgr;1 and &bgr;2 are thoughtExpand
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Distinctive ERK and p38 signaling in remote and infarcted myocardium during post‐MI remodeling in the mouse
Global activation of MAP kinases has been reported in both human and experimental heart failure. Chronic remodeling of the surviving ventricular wall after myocardial infarction (MI) involves bothExpand
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Identification of α1L‐adrenoceptor in mice and its abolition by α1A‐adrenoceptor gene knockout
The α1L‐adrenoceptor has pharmacological properties that distinguish it from three classical α1‐adrenoceptors (α1A, α1B and α1D). The purpose of this was to identify α1L‐adrenoceptors in mice and toExpand
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Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.
After myocardial infarction, a poorly contracting nonischemic border zone forms adjacent to the infarct. The cause of border zone dysfunction is unclear. The goal of this study was to determine theExpand
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Antioxidant activity of medicinal herb Rhodococcum vitis-idaea on galactosamine-induced liver injury in rats.
Aim of the study was to evaluate in vivo antioxidant action of medicinal herb Rhodococcum vitis-idaea (Rh.v) on galactosamine (GalN)-induced rat liver toxicity. The results showed that theExpand
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A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart
Summary The authors used 52 nonfailing and failing human hearts to develop a simple, high throughput left ventricular myocardial slice model that is stable by ATP and viability assays for at least 3Expand
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