• Publications
  • Influence
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and cancer. We performed RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNAExpand
  • 687
  • 91
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
Recent genome-wide association studies (GWASs) have identified a locus on chromosome 1p13 strongly associated with both plasma low-density lipoprotein cholesterol (LDL-C) and myocardial infarctionExpand
  • 894
  • 39
IL‐29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection
Early, vigorous intrahepatic induction of interferon (IFN)‐stimulated gene (ISG) induction is a feature of hepatitis C virus (HCV) infection, even though HCV inhibits the induction of type I IFNs inExpand
  • 120
  • 10
Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen (PSCA) gene, as a risk factor for bladder cancer. To fine-map this region, we imputedExpand
  • 71
  • 5
A variant upstream of IFNL 3 ( IL 28 B ) creating a novel interferon gene IFNL 4 is associated with impaired clearance of hepatitis C virus
Ludmila Prokunina-Olsson, Brian Muchmore, Wei Tang, Ruth M. Pfeiffer, Heiyoung Park, Harold Dickensheets, Dianna Hergott, Patricia Porter-Gill, Adam Mumy, Indu Kohaar, Sabrina Chen, Nathan Brand,Expand
  • 114
  • 3
  • PDF
The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.
A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1Expand
  • 19
  • PDF
IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.
Among 1369 Urban Health Study participants, we evaluated genetic models for the association of IL28B genotype (rs12979860 and rs8099917) with hepatitis C virus (HCV) clearance. For rs12979860,Expand
  • 19
The IFN-λ4 Conundrum: When a Good Interferon Goes Bad.
Since its discovery in 2013, interferon lambda 4 (IFN-λ4) has received a reputation as a paradoxical type III IFN. Difficulties in detecting IFN-λ4, especially in secreted form even led to questionsExpand
  • 6
182 : Identification and characterization of interferon-λ4 (IFN-λ4), a novel class-2 cytokine which impairs clearance of hepatitis C virus
We have identified a novel human interferon, designated as interferon-λ4 (IFN-λ4) (Prokunina-Olsson et al., Nature Genetics, 2013). Inducible expression of IFNL4 , along with three related genes (Expand
  • 2