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Pathophysiology of sleep apnea.
Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence of anExpand
Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans
1 We recently showed that fatigue of the inspiratory muscles via voluntary efforts caused a time‐dependent increase in limb muscle sympathetic nerve activity (MSNA) ( St Croix et al. 2000 ). We nowExpand
Combined hypoxia and hypercapnia evokes long-lasting sympathetic activation in humans.
We studied ventilatory and neurocirculatory responses to combined hypoxia (arterial O2 saturation 80%) and hypercapnia (end-tidal CO2 + 5 Torr) in awake humans. This asphyxic stimulus produced aExpand
Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans
An important determinant of [H+] in the environment of the central chemoreceptors is cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a reduced cerebrovascularExpand
Exposure to hypoxia produces long-lasting sympathetic activation in humans.
The relative contributions of hypoxia and hypercapnia in causing persistent sympathoexcitation after exposure to the combined stimuli were assessed in nine healthy human subjects during wakefulness.Expand
Cerebrovascular response to carbon dioxide in patients with congestive heart failure.
RATIONALE Cerebrovascular reactivity to CO(2) provides an important counterregulatory mechanism that serves to minimize the change in H(+) at the central chemoreceptor, thereby stabilizing theExpand
Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans
1 We tested the hypothesis that reflexes arising from working respiratory muscle can elicit increases in sympathetic vasoconstrictor outflow to limb skeletal muscle, in seven healthy human subjectsExpand
Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries.
The goal of the present study was to evaluate the effects of relatively short-term chronic intermittent hypoxia (CIH) on endothelial function of resistance vessels in the skeletal muscle and cerebralExpand
Effects of age and training status on heart rate recovery after peak exercise.
Previous studies have shown that the kinetics of heart rate (HR) recovery are delayed in older individuals after exercise. This study was designed to determine whether this observation held when theExpand
Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment.
RATIONALE Impaired endothelium-dependent vasodilation has been documented in patients with sleep apnea. This impairment may result in blood flow dysregulation during apnea-induced fluctuations inExpand