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Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol
25 μM resveratrol can modulate the effects of As2O3 on enzymes involved in estrogen metabolism, and in immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), it is observed that it ameliorated As2 O3-induced cytotoxicity.
Estrogen Metabolism in African-American Women with and without Breast Cancer: A Pilot Study.
Higher DNA adduct ratios in women with breast cancer are found, which suggests that estrogen metabolism is out of balance, and the formation of estrogen-DNA adducts may exert a critical role in breast cancer initiation in AA women.