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Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population
It is suggested, for the first time, that common miRNA variants may not contribute to GBC susceptibility in North Indian population.
GSTT1, GSTM1 and GSTP1 genetic polymorphisms and interaction with tobacco, alcohol and occupational exposure in esophageal cancer patients from North India.
It is suggested that genetic polymorphisms of GSTT1, GSTM1, and GSTP1 are not associated with higher risk of esophageal cancer, however, interaction of smoking or alcohol with GSTM 1 null or GSTP 1 ile/ile moderately increases the risk for esophagal cancer in North Indian population.
Evaluation of Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility
This study suggests only marginal role of TLR 3 and 9 gene polymorphisms in cervical cancer susceptibility in North India; however, future studies in ethnically diverse populations may provide a more comprehensive involvement of innate immunity in cervicalcancer etiology in women worldwide.
Genetic polymorphism of glutathione S‐transferase genes (GSTM1, GSTT1 and GSTP1) and susceptibility to prostate cancer in Northern India
To examine the association of glutathione‐S‐transferase (GST) gene polymorphisms in patients with sporadic prostate cancer, in a North Indian population, as GSTs are active in detoxifying a wide
Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women.
The involvement of TLR 2 (-196 to -174 del) and TLR 4 (Thr399Ile) gene polymorphisms in cervical cancer susceptibility is highlighted and may be helpful in elucidation of immunobiological mechanisms associated with cervicalcancer susceptibility.
Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.
Overall, results indicate a differential role of genetic polymorphisms of sodium channels SCN1A and SCN2A in epilepsy susceptibility and drug response.
Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and precancerous lesions.
CagA positivity may be a risk factor for lymphoid follicle development but not for other precancerous lesions in a northern Indian population, and frequencies of TLR-4 Asp299Gly variants were comparable between patients and control subjects, and also between positive and negative groups of precancerously lesions in patients.
Association of Xenobiotic Metabolizing Enzymes Genetic Polymorphisms With Esophageal Cancer in Kashmir Valley and Influence of Environmental Factors
It is shown that GSTP1val/val and CYP2E1c1c2 genotypes/c2 allele increased the risk of ESCC and EADC, respectively, in the Kashmiri population; whereas GSTM3AB genotype imparted lower risk for both ES CC and E ADC.
Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine
The TNFA 308G > A polymorphism was found to be associated with MA, particularly in females, whereas the TNFB 252G >(A) polymorphism could not be found in genetic susceptibility to migraine on comparing the migraine patients with HC or TTH patients.
Genetic polymorphisms in GSTM1, GSTT1, GSTP1, GSTM3 and the susceptibility to gallbladder cancer in North India
This is the first paper showing ile/val genotypes and val allele of GSTP1 to be associated with higher risk of gallbladder cancer.