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Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids.
Goenlandicine may be a promising anti-AD agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO(-) scavenging and good ROS inhibitory capacities.
New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells.
Three new lanostante-type triterpene aldehydes, named lucialdehydes A-C (1-3), were isolated from the fruiting bodies of Ganoderma lucidum and showed cytotoxic effects on tested tumor cells.
Inhibition of human immunodeficiency virus type 1 reverse transcriptase and ribonuclease H activities by constituents of Juglans mandshurica.
From the stem-bark of Juglans mandshurica, two new naphthalenyl glucopyranosides exhibited the most potent inhibition of reverse transcriptase (RT) activity, while the latter compound also inhibited ribonuclease H (RNase H) activity with an IC50 of 39 microM, comparable in potency to illimaquinone used as a positive control.
Antifungal activity of magnolol and honokiol
Two neolignan compounds, magnolol and honokiol, were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi and showed significant inhibitory activities against Trichophyton mentagrophytes and Candida albicans.
Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum and showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.
Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells.
Six new highly oxygenated lanostane-type triterpenes were isolated from the spores of Ganoderma lucidum, together with known ganolucidic acid D and ganoderic acid C2, and the cytotoxicity of the compounds was carried out in vitro against Meth-A and LLC tumor cell lines.
The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium.
A human intestinal bacterium, Eubacterium (E.) sp. strain SDG-2, was tested for its ability to metabolize various (3R)- and (3S)-flavan-3-ols and their 3-O-gallates. This bacterium cleaved the C-ring
Anticholinesterase and antioxidant constituents from Gloiopeltis furcata.
Activity-directed isolation of the ethyl acetate, methylene chloride and n-hexane fractions of Gloiopeltis furcata resulted in the isolation of 18 compounds, whose structures were elucidated as 2-(3-hydroxy-5-oxotetrahydrofuran-3-yl)acetic acid, which most of the compounds isolated were lacking the scavenging activity on DPPH radical and ONOO(-).