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The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
The PD-1/PD-L1 interaction described here may be blocked by antibodies or by designed small-molecule drugs to lower inhibitory signaling that results in a stronger immune response. Expand
Crystal structure of soybean 11S globulin: Glycinin A3B4 homohexamer
Electrostatic analysis of the faces suggests that the interchain disulfide-containing face has high positive potential at acidic pH, which induces dissociation of the hexamer into trimers that may be susceptible to proteinases after seed imbibition. Expand
Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release.
It is proposed that uptake of the Fe(3+)-transferrin complex into an acidic endosome via receptor-mediated endocytosis will result in the protonation of both lysine residues, which lies below the pH of the structure determination and is, therefore, not positively charged. Expand
Crystal Structure of Exotype Alginate Lyase Atu3025 from Agrobacterium tumefaciens*
The structural analysis of H531A/ΔGGG and subsequent site-directed mutagenesis studies proposed the enzyme reaction mechanism, with His311 and Tyr365 as the catalytic base and acid, respectively. Expand
Crystal structure of soybean proglycinin A1aB1b homotrimer.
The crystal structure of proglycinin is similar to those of canavalin and phaseolin belonging to the 7 S globulin family, strongly supporting the hypothesis that both 7 S and 11 S globulins are derived from a common ancestor. Expand
A structural basis for depolymerization of alginate by polysaccharide lyase family-7.
The crystal structure and results of mutational analysis of Sphingomonas sp. Expand
Induced-fit motion of a lid loop involved in catalysis in alginate lyase A1-III.
  • B. Mikami, M. Ban, +7 authors K. Murata
  • Chemistry, Medicine
  • Acta crystallographica. Section D, Biological…
  • 1 September 2012
The structures of two mutants of a mannuronate-specific alginate lyase, A1-III, from Sphingomonas species A1 complexed with a tetrasaccharide substrate were determined by X-ray crystallography at around 2.2 Å resolution together with the apo form of the H192A mutant. Expand
A Redox-controlled Molecular Switch Revealed by the Crystal Structure of a Bacterial Heme PAS Sensor*
A novel redox-regulated molecular switch is proposed in which local heme-ligand switching may trigger a global “scissor-type” subunit movement that facilitates catalytic control of Escherichia coli redox sensor. Expand
Crystal structure of pullulanase: evidence for parallel binding of oligosaccharides in the active site.
The comparison suggested that the conformational difference around the active cleft, together with the domain organization, determines the different substrate specificities between pullulanase and isoamylase. Expand
Crystal structure of glycoside hydrolase family 78 alpha-L-Rhamnosidase from Bacillus sp. GL1.
To the authors' knowledge, this is the first report on the determination of the crystal structure of alpha-L-rhamnosidase and identification of its clan-L (alpha/alpha)(6)-barrel as a catalytic domain. Expand