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Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality.
RATIONALE Septic shock is a significant cause of morbidity and mortality in the pediatric population. Early recognition of septic shock and appropriate treatment increase survival rate; thus,Expand
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Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas
Introduction Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low muscle radiodensity due toExpand
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Metabolic Profiling of Serum Samples by 1H Nuclear Magnetic Resonance Spectroscopy as a Potential Diagnostic Approach for Septic Shock*
Objectives:To determine whether a nuclear magnetic resonance–based metabolomics approach can be useful for the early diagnosis and prognosis of septic shock in ICUs. Design:Laboratory-based study.Expand
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Impact of dietary fiber supplementation on modulating microbiota-host-metabolic axes in obesity.
Low dietary fiber intake is associated with higher rates of microbiota-associated chronic diseases such as obesity. Low-fiber diets alter not only microbial composition but also the availability ofExpand
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Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit
IntroductionSeptic shock is a major life-threatening condition in critically ill patients and it is well known that early recognition of septic shock and expedient initiation of appropriate treatmentExpand
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Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis
Osteoarthritis (OA) is a leading cause of chronic joint pain in the older human population. Diagnosis of OA at an earlier stage may enable the development of new treatments to one day effectivelyExpand
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Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis
Joint injuries and subsequent osteoarthritis (OA) are the leading causes of chronic joint disease. In this work, we explore the possibility of applying magnetic resonance spectroscopy‐basedExpand
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Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis.
The risk of developing post-traumatic osteoarthritis (PTOA) following joint injury is high. Furthering our understanding of the molecular mechanisms underlying PTOA and/or identifying novelExpand
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Metabolomics in critical care medicine: a new approach to biomarker discovery.
PURPOSE To present an overview and comparison of the main metabolomics techniques (1H NMR, GC-MS, and LC-MS) and their current and potential use in critical care medicine. SOURCE This is a focusedExpand
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Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis
IntroductionThe first steps in goal-directed therapy for sepsis are early diagnosis followed by appropriate triage. These steps are usually left to the physician’s judgment, as there is no acceptedExpand
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