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Syringa vulgaris bark as a source of compounds affecting the release of inflammatory mediators from human neutrophils and monocytes/macrophages
Abstract In traditional European medicine, common lilac (Syringa vulgaris L., Oleaceae) bark has been used in the form of an infusion, decoction or alcoholic extract as an antipyretic and a cold and
Gas Evolution in Operating Lithium-Ion Batteries Studied In Situ by Neutron Imaging
TLDR
The results suggest that metal dissolution in the electrolyte and decomposition products resulting from the high potentials adversely affect the gas generation, particularly in the first charge cycle (i.e., during graphite solid-electrolyte interface layer formation).
Impact of the aryl substituent kind and distance from pyrimido[2,1-f]purindiones on the adenosine receptor selectivity and antagonistic properties.
TLDR
Contrary to dipropyl derivatives, in the group of dimethyl (un)substituted arylalkyl pyrimido[2,1-f]purindiones selective mainly adenosine A(2A) receptor antagonists were identified.
Tricyclic oxazolo[2,3-f]purinediones: potency as adenosine receptor ligands and anticonvulsants.
TLDR
Oxazolopurinediones were evaluated in vivo as anticonvulsants in MES and ScMet tests and examined for neurotoxicity in mice (ip), accompanied by significant neurotoxicity, and SAR and QSAR studies stressed the importance of lipophilic 7-substituents for both types of pharmacological activity.
Gas Evolution in LiNi0.5Mn1.5O4/Graphite Cells Studied In Operando by a Combination of Differential Electrochemical Mass Spectrometry, Neutron Imaging, and Pressure Measurements.
TLDR
The results from DEMS analysis suggest that the Ni redox couples play a profound role in the evolution of CO2 at the LNMO/electrolyte interface and it is shown that the cycling stability and capacity retention of LN MO/graphite cells can be considerably improved by a simple cell formation procedure.
Electrochemical Cross-Talk Leading to Gas Evolution and Capacity Fade in LiNi0.5Mn1.5O4/Graphite Full-Cells
Continuous destruction of the solid electrolyte interphase (SEI) on the graphite-based negative electrode during cycling operation is a significant degradation mechanism that raises safety concerns
Isolation of spilanthol from Acmella oleracea based on Green Chemistry and evaluation of its in vitro anti-inflammatory activity
Abstract Acmella oleracea (jambu) is a South American plant whose pharmacological properties include antimalarial, anesthetic, and anti-inflammatory activities. However, the compounds contributing to
Hydroxycinnamoyl derivatives and secoiridoid glycoside derivatives from Syringa vulgaris flowers and their effects on the pro-inflammatory responses of human neutrophils.
TLDR
Oleonuezhenide (12), oleoside 11-methyl ester (16) and oleoacteoside (26) at the concentration of 50μM were able to induce the surface expression of interleukin 10 receptor, which is suppressed by the incubation of monocyte/macrophage cells with LPS.
Effects of Phytochemically Characterized Extracts From Syringa vulgaris and Isolated Secoiridoids on Mediators of Inflammation in a Human Neutrophil Model
TLDR
It is demonstrated that common lilac, which is a traditionally used medicinal plant in Europe, is a valuable source of active compounds, especially neooleuropein, which appeared to be the most active compound in the inhibition of cytokine production by attenuating the MAP kinase pathways.
New developments in A1 and A2 adenosine receptor antagonists
The aim of this article is to briefly present progress in the development of the potent adenosine receptor (AR) antagonists with high selectivity for either A1, A2A, or A2B ARs. The structural
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