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Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein
TLDR
The structures show that inhibitors bind in membrane-embedded pockets of FLAP, which suggests how these inhibitors prevent arachidonic acid from binding to FLAP and subsequently being transferred to 5-lipoxygenase, thereby preventing leukotriene biosynthesis.
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Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
TLDR
The crystal structure of the protease of the human immunodeficiency virus type 1 (HIV-1), which releases structural proteins and enzymes from viral polyprotein products, has been determined to 3 Å resolution and suggests a mechanism for the autoproteolytic release of protease and a role in the control of virus maturation.
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A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
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The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.
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Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors
TLDR
These studies indicate that the induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems.
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Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.
The mode of binding of acetyl-pepstatin to the protease from the human immunodeficiency virus type 1 (HIV-1) has been determined by x-ray diffraction analysis. Crystals of an acetyl-pepstatin-HIV-1…
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Site-directed mutagenesis of glutathione S-transferase YaYa. Important roles of tyrosine 9 and aspartic acid 101 in catalysis.
TLDR
Results indicate that tyrosine 9 is directly responsible for the lowering of the pKa of the sulfhydryl group of glutathione, presumably due to the stabilization of the thiolate anion through hydrogen bonding with the hydroxyl group of tyrosines.
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Positions of His‐64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors
TLDR
The 3‐dimensional structure of human carbonic anhydrase II complexed with 3 structurally related inhibitors, la, lb, and lc, has been determined by X‐ray crystallographic methods and the major reason lc binds tighter to HCAII than does la or lb appears to be entropy.
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FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.
TLDR
Structural analysis of the three-dimensional structure of the FK-506-ligand complex with respect to residues conserved among these proteins suggests a small number of surface residues near the bound ligands that may play a critical role in interactions between the protein-drug complex and calcineurin.
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A Role for the Aspartyl Protease from the Human Immunodeficiency Virus Type 1 (HIV‐1) in the Orchestration of Virus Assembly
TLDR
This work proposes a comprehensive virus assembly model that highlights the role of HIV-1 PR, suggests further experiments to verify the validity of the model, and poses specific questions relevant to the ultimate exploitation of AIDS-1 protease as a therapeutic target.
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