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Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
It is demonstrated that gonadal steroids are necessary for the maintenance of normal adult CA1 hippocampal pyramidal cell structure and implies that CA1 pyramsidal cell dendritic spine density may fluctuate during the normal rat estrous cycle. Expand
Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
The majority of newly born cells in the adult dentate gyrus differentiate into neurons, and cells that were immunoreactive for glial fibrillary acidic protein typically showed morphologic characteristics of radial glia at all time-points. Expand
Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
Both the hippocampus and the medial prefrontal cortex (mPFC) play an important role in the negative feedback regulation of hypothalamic-pituitary-adrenal (HPA) activity during physiologic andExpand
Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons
These results demonstrate rapid and ongoing dendritic plasticity in a specific population of hippocampal neurons in experimentally unmanipulated animals. Expand
Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress
It appears unlikely that sex differences in the corticosteroid-binding globulin and corticosterone response can account for these morphological differences found in males and females. Expand
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress.
The results suggest that neurons are produced in the dentate gyrus of adult monkeys and that the rate of precursor cell proliferation can be affected by a stressful experience. Expand
Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus
The results suggest that adult neurogenesis in the dentate gyrus of the rat is altered by afferent input, via NMDA receptors, and may be regulated naturally by endogenous excitatory amino acids. Expand
Adrenal hormones suppress cell division in the adult rat dentate gyrus
The results suggest that adrenal hormones normally suppress the birth of both glia and neurons in the adult rat dentate gyrus. Expand
Sex and seasonal changes in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles
There were large fluctuations across the season in the rate of cell proliferation in the dentate gyrus of adult female meadow voles, which may be related to known changes in spatial learning in the meadow vole and provide insights into changes in the hippocampus that occur in other species, including primates. Expand
Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery
The hypothesis that disease-related PFC dysfunction is a consequence of network disruption secondary to altered structural and functional plasticity and that circuitry reestablishment may underlie elements of recovery is supported. Expand