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Changes in regional cerebral blood flow during brain maturation in children and adolescents.
Cognitive development of the child seems to be related to changes in blood flow of the corresponding brain regions, which was studied by SPECT using 133Xe in 42 children considered as neurologically normal. Expand
FDG accumulation and tumor biology.
Improved FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway, and clinical use is therefore recommended in carefully selected patients. Expand
Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia
Results suggest that cortical D2 dopamine receptors are a common target of traditional and atypical antipsychotics for therapeutic action and higher in vivo binding to the D2 receptors in the cortex than in the basal ganglia is suggested as an indicator of favourable profile for a putative antipsychotic compound. Expand
In Vivo Extrastriatal and Striatal D2 Dopamine Receptor Blockade by Amisulpride in Schizophrenia
Dose-dependent differential binding profiles of amisulpride to D2 receptors in extrastriatal and striatal regions were demonstrated, and two therapeutic ranges of plasma concentrations for negative and positive schizophrenic symptoms, respectively, are suggested. Expand
Quantitation of Extrastriatal D2 Receptors Using a Very High-Affinity Ligand (FLB 457) and the Multi-Injection Approach
It is demonstrated that after a tracer injection, most of the PET-measured radioactivity in the cerebellum results from the labeled ligand bound to receptor sites, which led to a precise knowledge of the FLB 457 kinetics in all brain regions. Expand
Precursor synthesis and radiolabelling of the dopamine D2 receptor ligand (11C)raclopride from (11C)methyl triflate
Desmethyl-raclopride was synthesized via a straightforward, three-step synthetic approach and used for the preparation of [11C]raclopride from [11C]methyl triflate. Conditions for the radiolabellingExpand
Positron emission tomography with 11C CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated cardiomyopathy.
PET appears to be a safe and reliable method of assessing in vivo changes in the number of left ventricular beta-adrenergic receptor sites of patients with idiopathic cardiomyopathy. Expand
Preparation of [76Br]FLB 457 and [76Br]FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET.
Both FLB 457 and FLB 463, two substituted benzamides with high affinity for the dopamine D-2 receptors, were labeled with bromine-76 for PET investigations and there was a rapid and high uptake in the striatum during PET examinations, during which the striatal radioactivity concentration reached a plateau 1 h postinjection (p.i). Expand
Radioionidation reactions for radiopharmaceuticals : compendium for effective synthesis strategies
INTRODUCTION.- IODINE RADIONUCLIDES. Physical properties and areas of application. Radiochemical and radionuclidic purity. Specific radioactivity. Production of iodine radionuclides. Production ofExpand
A new generator for ionic gallium-68.
To meet the needs created by the rapid development of positron tomographic techniques, a new Ge-68 leads to Ga-68 generator has been developed that provides a sterile solution of Ga- 68 in ionic form, ready for use in the preparation of many radiopharmaceuticals. Expand