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Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist
- R. D. de Campos, R. V. Alves, J. Calixto
- Biology, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 11 August 1999
The novel non-peptide BK B2 receptor antagonist NPC 18884 produces rapid onset, potent and relatively long-lasting oral antinociceptive and oedema inhibition properties.
Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo.
Co-treatment with a p38 inhibitor, such as SCIO-469, may enhance the cytotoxicity of bortezomib by modulating pro-apoptotic and anti-APoptotic factors in MM cells, suggesting great potential for co-therapy.
Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist.
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors
Pharmacological Properties of SD-282 – An α-Isoform Selective Inhibitor for p38 MAP Kinase
The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component.
Inhibition of p38α MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-XL, Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo
Co-treatment with a p38 inhibitor, such as SCIO-469, may enhance the cytotoxicity of bortezomib by modulating pro-APoptotic and anti-apoptotic factors in MM cells, suggesting great potential for co-therapy.
Piperidine-based heterocyclic oxalyl amides as potent p38 alpha MAP kinase inhibitors.
Preparation of 2-aryl and 2-aryloxymethyl imidazo[1,2-a]pyridines and related compounds
A series of substituted 2-aryl imidazo[1,2-a]pyridines has been prepared in which a variety of substituents are introduced on the 4′-position of the phenyl ring and on the 3, 5, 6 or 7 position of…
NEW RING SYSTEMS FROM 1,2-BENZISOTHIAZOLE-1,1-DIOXIDES AND RELATED COMPOUNDS
A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production.
- J. Higaki, S. Chakravarty, B. Cordell
- Biology, ChemistryJournal of medicinal chemistry
- 23 September 1999
It is suggested that dipeptide aldehydes related to carbobenzoxyl-valinyl-phenylalanal inhibit Abeta through similar mechanisms and the utility of a combinatorial synthesis approach to rapidly identify potent inhibitors of Abeta production is demonstrated.