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Extensive changes in DNA methylation are associated with expression of mutant huntingtin
The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT)Expand
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Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements.
MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make itExpand
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Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development
Significance Toll-like receptors (TLR) are involved in pathogen recognition and defense in organisms from fruit flies to humans. Recent genomic evidence suggests that TLRs and their downstreamExpand
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Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance.
Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety ofExpand
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Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver
CTCF and cohesin are key drivers of 3D-nuclear organization, anchoring the megabase-scale Topologically Associating Domains (TADs) that segment the genome. Here, we present and validate aExpand
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Characterization of hamster tumors induced by simian virus 40 small t deletion mutants as true histiocytic lymphomas.
Random bred Syrian hamsters given s.c. injections of SV40 small t deletion mutants dl883, dl884, and dl890 rapidly develop reticulum cell sarcomas in the abdominal cavity in addition to slowlyExpand
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Deletion mutations in the small t antigen gene alter the tissue specificity of tumors induced by simian virus 40.
Subcutaneous injection of wild-type simian virus 40 into Syrian hamsters normally induces fibrosarcomas at the injection site. We showed that subcutaneous injection of three different small tExpand
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Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.
Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type 2 diabetes. The molecular mechanisms that mediate this response occur across many highly complexExpand
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CTCF and Cohesin link sex-biased distal regulatory elements to sex-biased gene expression in mouse liver
More than 1,000 genes are differentially expressed between male and female mouse liver. However, ∼90% of 4,000 sex-differential open chromatin regions harboring regulatory elements implicated inExpand
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Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARα regulates anaerobic glycolysis
Diet plays a crucial role in shaping human health and disease. Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (CR) diets can improveExpand
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