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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
The crystal structures of six complexes between aminoglycoside antibiotics (neamine, gentamicin C1A, kanamycin A, ribostamycin, lividomycin A and neomycin B) and oligonucleotides containing theExpand
A universal mode of helix packing in RNA
RNA molecules fold into specific three-dimensional shapes to perform structural and catalytic functions. Large RNAs can form compact globular structures, but the chemical basis for close helicalExpand
The cspA mRNA is a thermosensor that modulates translation of the cold-shock protein CspA.
Cold induction of cspA, the paradigm Escherichia coli cold-shock gene, is mainly subject to posttranscriptional control, partly promoted by cis-acting elements of its transcript, whose secondaryExpand
Molecular modeling of the three-dimensional structure of the bacterial RNase P holoenzyme.
Bacterial ribonuclease P (RNase P), an enzyme involved in tRNA maturation, consists of a catalytic RNA subunit and a protein cofactor. Comparative phylogenetic analysis and molecular modeling haveExpand
RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures.
This paper is a report of a second round of RNA-Puzzles, a collective and blind experiment in three-dimensional (3D) RNA structure prediction. Three puzzles, Puzzles 5, 6, and 10, representedExpand
Staphylococcus aureus RNAIII Binds to Two Distant Regions of coa mRNA to Arrest Translation and Promote mRNA Degradation
Staphylococcus aureus RNAIII is the intracellular effector of the quorum sensing system that temporally controls a large number of virulence factors including exoproteins and cell-wall-associatedExpand
Speciation of a group I intron into a lariat capping ribozyme
Significance We report the crystal structures of precleavage and postcleavage forms of the lariat-capping (LC) ribozyme. The structures show how domains from an ancestral group I ribozyme haveExpand
LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex
As obligatory intracellular parasites, viruses rely on cellular machines to complete their life cycle, and most importantly they recruit the host ribosomes to translate their mRNA. The Hepatitis CExpand
RNA tectonics: towards RNA design.
Our understanding of the structural, folding and catalytic properties of RNA molecules has increased enormously in recent years. The discovery of catalytic RNA molecules by Sidney Altman and TomExpand
Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme
Compact but non-native intermediates have been implicated in the hierarchical folding of several large RNAs, but there is little information on their structure. In this article, ribonuclease andExpand