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Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
The pattern of inhibition for the phosphatase in myosin B is similar to that of the type-1 enzyme, and the effects of both compounds on various phosphatases are screened. Expand
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation.
Transient deactivation of phosphatase 2A might enhance transmission of cellular signals through kinase cascades within cells through kinases within cells. Expand
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
Immunoblotting experiments, comigration on 2D gels, and 2D analysis of limit chymotryptic digests demonstrated that the 63 kd protein, present in the middle T complex in approximately equimolar ratio to the 36 kdprotein, is a known regulatory subunit of the PP2A holoenzyme. Expand
Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A
The results demonstrate that type 1 and type 2 maxi-K+ channels are substrates for PK-A, and phosphorylation can shift the open probability of channels in either direction, by a mechanism involving multiple phosphorylated sites, and dephosphorylation alters the Ca2+/voltage sensitivity of these channels. Expand
Use of substituted (benzylidineamino)guanidines in the study of guanidino group specific ADP-ribosyltransferase.
A number of substituted (benzylidineamino)guanidines with different substitutents in the benzene nucleus are synthesized by coupling substituted benzaldehydes with aminoguanidine, and these compoundsExpand
Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel.
There may be an endogenous protein kinase activity firmly associated with a large conductance Ca(2+)-activated K+ channel from rat brain that is increased by the addition of adenosine triphosphate to the cytoplasmic side of the channel. Expand
Comparison of the reaction progress of calcineurin with Mn2+ and Mg2+.
The 18(V/K)nonbridge isotope effect indicated that the dianion was the substrate for catalysis, and that a dissociative transition state was operative for the phosphoryl transfer. Expand
Metallothionein-3 Is a Component of a Multiprotein Complex in the Mouse Brain
Insights are provided into the involvement ofMT-3 in a multiprotein complex, which will be used to understand the biological activity of MT-3 and its role in neurological disease. Expand
New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion
These new partner proteins—Exo84p, 14-3-3 Zeta, α and β Enolase, Aldolase C, Malate dehydrogenase, ATP synthase, and Pyruvate kinase—along with those previously identified have now been classified into three functional groups: transport and signaling, chaperoning and scaffolding, and glycolytic metabolism. Expand
Differences between Mg(2+) and transition metal ions in the activation of calcineurin.
Circular dichroism showed that metal ions increased the alpha-helical content of calcineurin, but little significant differences in the spectra were identified between using activating and nonactivating metal ions. Expand