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LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
TLDR
It is shown that LDL-receptor-related protein 6 (LRP6) is a specific, high-affinity receptor for Dkk1 and Dkk2, illustrating the modulation of LRP signalling by antagonists. Expand
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
TLDR
Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates that functionally cooperate with Dkk1 to block Wnt/beta-catenin signalling. Expand
A Draft Sequence for the Genome of the Domesticated Silkworm (Bombyx mori)
  • Q. Xia, Zeyang Zhou, +90 authors Huanming Yang
  • Biology, Medicine
  • Science
  • 10 December 2004
TLDR
A draft sequence for the genome of the domesticated silkworm (Bombyx mori), covering 90.9% of all known silkworm genes is reported, which exceeds the estimated gene count for Drosophila melanogaster. Expand
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
TLDR
Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates that functionally cooperate with Dkk1 to block Wnt/β-catenin signalling. Expand
Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling.
TLDR
It is shown that Kremen2 (Krm2) regulates Dkk2 activity during Wnt signaling, and interaction with Krm2 is mediated by the second cysteine-rich domain of Dkks, suggesting that Krm 2 can function as a switch that turns DKK2 from an activator into an inhibitor of Wnt/lRP6 signaling. Expand
Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning
TLDR
The results indicate that Krm proteins function in a Wnt inhibition pathway regulating early AP patterning of the central nervous system (CNS) during Xenopus embryogenesis. Expand
The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of β-Catenin
TLDR
In colon cancer cells with stimulated Wnt signaling, knockdown of RNF220 or USP7 impairs Wnt signaled cells and expression of Wnt target genes, suggesting a potentially novel role of R NF220 in Wnt-related tumorigenesis. Expand
RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination.
TLDR
RNF220 (RING finger protein 220) is identified as a novel ubiquitin ligase for Sin3B, a scaffold protein of the Sin3/HDAC (histone deacetylase) corepressor complex that can be regulated by the ubiquitIn-proteasome system. Expand
Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation.
TLDR
XZ MYND8 is co-expressed with XRCOR2 in the nervous system and overexpression of XZMYND8 inhibits neural differentiation in Xenopus embryos, revealing a RCOR2/ZmyND8 complex which might be involved in the regulation of neural differentiation. Expand
Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells
Aberrant Wnt/β-catenin signaling has been strongly associated with the tumorigenesis of human colorectal cancer. Inhibitors of this pathway may then offer therapeutic strategies as well asExpand
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