Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
 Glutathione reductase
Purification and characterization of the flavoenzyme glutathione reductase from rat liver.
Glutathione transferases--structure and catalytic activity.
The glutathione transferases are recognized as important catalysts in the biotransformation of xenobiotics, including drugs as well as environmental pollutants. Multiple forms exist, and numerous…
The isoenzymes of glutathione transferase.
- B. Mannervik
- BiologyAdvances in Enzymology and Related Subjects
- 22 November 2006
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.
- K. Berhane, M. Widersten, A. Engström, J. Kozarich, B. Mannervik
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 15 February 1994
The results show that glutathione transferases may play an important role in cellular detoxication of electrophilic alpha, beta-unsaturated carbonyl compounds produced by radical reactions, lipid peroxidation, ionizing radiation, and drug metabolism.
Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.
- B. Mannervik, P. Ålin, H. Jörnvall
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1985
It is suggested that the similarities of the isoenzymes in a class reflect evolutionary relationships and that the classification applies generally.
4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase
Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation.
4-Hydroxynonenal and other reactive electrophiles produced by oxidative metabolism have been linked to aging, atherosclerosis, cataract formation, Parkinson's disease and Alzheimer's disease, as well as other degenerative human conditions, suggesting that human GST A4-4 fulfills an important protective role and that variations in its expression may have significant pathophysiological consequences.