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Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine‐treated kidney graft patients after multiple doses
To study pravastatin and lovastatin pharmacokinetic and pharmacodynamic effects and their interactions with cyclosporine (INN, ciclosporin) in kidney transplant patients after single and multipleExpand
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Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man.
The lysine salt of d,l-2-(4-isobutylphenyl)-propionic acid (ibuprofen lysine) was administered as a single oral dose of 500 mg by means of commercially available coated tablets (Imbun).* To assessExpand
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Pharmacodynamic effects of dual neutral endopeptidase–angiotensin‐converting enzyme inhibition versus angiotensin‐converting enzyme inhibition in humans
There is currently no clear evidence that dual neutral endopeptidase–angiotensin‐converting enzyme inhibitors have effects on angiotensin‐converting enzyme, renin, or blood pressure that areExpand
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Comparison of the pharmacokinetics of fosinoprilat with enalaprilat and lisinopril in patients with congestive heart failure and chronic renal insufficiency.
AIMS To compare the serum pharmacokinetics of fosinoprilat with enalaprilat and lisinopril after 1 and 10 days of dosing with fosinopril, enalapril and lisinopril. METHODS Patients with congestiveExpand
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Effects of Acetaminophen, Naproxen, and Acetylsalicylic Acid on Tapentadol Pharmacokinetics: Results of Two Randomized, Open‐Label, Crossover, Drug‐Drug Interaction Studies
Study Objective. To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects.
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Pharmacokinetics of Single-Dose Oral Stavudine in Subjects with Renal Impairment and in Subjects Requiring Hemodialysis
ABSTRACT Two open-label studies assessed the pharmacokinetics of single orally administered doses of 40 mg of stavudine in subjects with renal impairment. In one study (study I), 15 subjects withExpand
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A thorough QT/QTc study of multiple doses of tapentadol immediate release in healthy subjects.
OBJECTIVE This randomized, double-blind, placebo- and positive-controlled 4-way crossover study evaluated the effects of tapentadol immediate release (IR) on the QT/QTc interval. MATERIALS ANDExpand
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Comparison of pravastatin and lovastatin in renal transplant patients receiving cyclosporine.
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Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects
TOC summary The analgesic/antihyperalgesic efficacy and dose‐response relationship of 2 opioids was demonstrated in a human experimental algesimetric model using laser stimuli applied to sensitizedExpand
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Irbesartan does not affect the steady-state pharmacodynamics and pharmacokinetics of warfarin
AbstractObjectives: To determine whether the initiation or titration of irbesartan alters the pharmacodynamics and/or pharmacokinetics of warfarin in a clinically significant manner, therebyExpand
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