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Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine‐treated kidney graft patients after multiple doses
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Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man.
TLDR
Drug tolerability was excellent for the oral administration of ib uprofen lysine as well as for the intravenous treatments with ibuprofen free acid, and from the results of intravenous injections one can deduce linear ibup rofen pharmacokinetics within the considered dosage range.
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Comparison of the pharmacokinetics of fosinoprilat with enalaprilat and lisinopril in patients with congestive heart failure and chronic renal insufficiency.
TLDR
Fosinoprilat exhibits significantly less accumulation than enalaprilat or lisinopril in patients with CHF and renal insufficiency, most probably because fosinobrilat is eliminated by both the kidney and liver, and increased hepatic elimination can compensate for reduced renal clearance in Patients with kidney dysfunction.
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Effects of Acetaminophen, Naproxen, and Acetylsalicylic Acid on Tapentadol Pharmacokinetics: Results of Two Randomized, Open‐Label, Crossover, Drug‐Drug Interaction Studies
TLDR
Evaluating the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects found them to be safe and effective.
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Pharmacokinetics of Single-Dose Oral Stavudine in Subjects with Renal Impairment and in Subjects Requiring Hemodialysis
TLDR
The recommended dosing rate for subjects requiring hemodialysis was the same as that proposed for those with severe renal impairment not requiring heModialysis; however, dosing was recommended to follow hemodIALysis and to occur at the same time each day.
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A thorough QT/QTc study of multiple doses of tapentadol immediate release in healthy subjects.
TLDR
Therapeutic and supratherapeutic doses of tapentadol do not affect the QT/QTc interval.
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Pharmacodynamic effects of dual neutral endopeptidase–angiotensin‐converting enzyme inhibition versus angiotensin‐converting enzyme inhibition in humans
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Comparison of pravastatin and lovastatin in renal transplant patients receiving cyclosporine.
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Fosinopril/hydrochlorothiazide: single dose and steady-state pharmacokinetics and pharmacodynamics.
TLDR
In renally impaired subjects fosinopril and HCTZ can be coadministered without undue increases in fos inoprilat concentrations or any clinically significant pharmacodynamic effects.
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Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects
View on Wolters Kluwer
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