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Identification and Functional Characterization of microRNAs Involved in the Malignant Progression of Gliomas
Diffuse astrocytoma of World Health Organization (WHO) grade II has an inherent tendency to spontaneously progress to anaplastic astrocytoma WHO grade III or secondary glioblastoma WHO grade IV. WeExpand
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Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR-amplifiedExpand
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Molecular Diagnostics of Gliomas Using Next Generation Sequencing of a Glioma‐Tailored Gene Panel
Current classification of gliomas is based on histological criteria according to the World Health Organization (WHO) classification of tumors of the central nervous system. Over the past years,Expand
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Unraveling the Glioma Epigenome—From Molecular Mechanisms to Novel Biomarkers and Therapeutic Targets
Epigenetic regulation of gene expression by DNA methylation and histone modification is frequently altered in human cancers including gliomas, the most common primary brain tumors. In diffuseExpand
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Practical implications of integrated glioma classification according to the World Health Organization classification of tumors of the central nervous system 2016
Purpose of review Morphological features identifiable by light microscopy have been the basis of brain tumor diagnostics for many decades. The revised WHO classification of tumors of the centralExpand
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Role of microRNAs Located on Chromosome Arm 10q in Malignant Gliomas
Deletions of chromosome arm 10q are found in most glioblastomas and subsets of lower grade gliomas. Mutations in the PTEN gene at 10q23.3 are restricted to less than half of the 10q‐deleted gliomas,Expand
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Bericht aus der Praxis/Practice Report: How to successfully establish PAL in medical education. 10 tips to succeed in PAL-based courses in undergraduate medical education (UGME).
This article aims to provide useful suggestions for the implementation of new courses with peer-assisted learning (PAL) in undergraduate medical education (UGME). It presents 10 key tips for needsExpand
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Assessing quality and functionality of DNA isolated from FFPE tissues through external quality assessment in tissue banks
Abstract Background: Biobanks are becoming increasingly important for assessment of disease risk as well as identification and validation of new diagnostic biomarkers and druggable targets. TheExpand
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BACKGROUND: Molecular testing for MGMT promoter methylation has become of clinical importance in the diagnostic assessment of malignant gliomas since test results may guide therapeutic decisionExpand
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Identification and functional analyses of microRNAs involved in the malignant progression of astrocytic gliomas
Diffuse Astrozytome des WHO (World Health Organization) Grades II tendieren zur spontanen Progression zu anaplastischen Astrozytomen (WHO Grad III) oder sekundaren Glioblastomen (WHO Grad IV).Expand
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