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Biology of Mammalian Photoperiodism and the Critical Role of the Pineal Gland and Melatonin
In mammals, photoperiodic information is transformed into a melatonin secretory rhythm in the pineal gland (high levels at night, low levels during the day). Melatonin exerts its effects in discreteExpand
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New selective ligands of human cloned melatonin MT1 and MT2 receptors
Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, namely MT1 or MT2Expand
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Control of sheep and goat reproduction: Use of light and melatonin
Abstract Breeds of sheep and goats from temperate latitudes exhibit seasonal variations of breeding activity which are controlled by annual photoperiodic changes. Short days (SD) stimulate sexualExpand
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Association Between Expression of Reproductive Seasonality and Alleles of the Gene for Mel1a Receptor in the Ewe1
Abstract To determine whether a link exists between reproductive seasonality and the structure of the gene for melatonin receptor Mel1a, the latter was studied in two groups of Mérinos d'Arles (MA)Expand
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High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus.
Melatonin has been implicated in several neurotropic effects, but few studies have investigated the bioavailability of melatonin in the brain. The discovery of periventricular sites of actionExpand
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Melatonin Activates Brain Dopaminergic Systems in the Eel with an Inhibitory Impact on Reproductive Function
In the eel, a deficit in gonadotrophin‐releasing hormone (GnRH) and a strong dopaminergic (DA) inhibition are responsible for the blockade of gonad development if silver eels are prevented from theirExpand
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Evidence for an annual reproductive rhythm independent of food availability in male Creole goats in subtropical northern Mexico.
The aim of this study was to determine if there is a seasonal pattern of sexual activity dependent on food availability in male Creole goats in subtropical Mexico. The study was conducted in theExpand
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GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals
BackgroundThe melatonin receptor subfamily contains three members Mel1a, Mel1b and Mel1c, found in all vertebrates except for Mel1c which is found only in fish, Xenopus species and the chicken.Expand
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GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals
BackgroundThe melatonin receptor subfamily contains three members Mel1a, Mel1b and Mel1c, found in all vertebrates except for Mel1c which is found only in fish, Xenopus species and the chicken.Expand
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Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205.
The nocturnal increase in circulating melatonin in vertebrates is regulated by the activity of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the melatonin pathway (serotoninExpand
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