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Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis.
TLDR
It is concluded that Wolbachia may have a mitochondrion-like function in the soma, generating ATP for its host, and suggests a role in diverting the immune system toward an ineffective antibacterial response.
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Wolbachia variability and host effects on crossing type in Culex mosquitoes
Wolbachia is a common maternally inherited bacterial symbiont able to induce crossing sterilities known as cytoplasmic incompatibility (CI) in insects. Wolbachia-modified sperm are unable to complete…
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Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
TLDR
This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future in terms of ability to control the human disease.
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Comparative genomics of the major parasitic worms
TLDR
This is the broadest comparative study to date of the genomes of parasitic and non-parasitic worms and provides a transformative new resource for the research community to understand and combat the diseases that parasitic worms cause.
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Extracellular Onchocerca-derived small RNAs in host nodules and blood
TLDR
Comparison to European control serum illuminates the scope for false-positives, warranting caution in criteria that should be applied to identification of biomarkers of infection, and confirms the conserved nature of RNA secretion by diverse nematodes.
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Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species).
TLDR
Results unequivocally demonstrate the macrofilaricidal potential of tetracyclines against Onchocerca infection and suggest that intermittent, protracted administration will be more effective than continuous shorter term treatment.
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The Tick Cell Biobank: A global resource for in vitro research on ticks, other arthropods and the pathogens they transmit
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Breakdown of coevolution between symbiotic bacteria Wolbachia and their filarial hosts
TLDR
The results show a general overestimation of Wolbachia occurrence and support the hypothesis of an ancestral absence of infection in the nematode phylum, and suggest that supergroup C is the basal Wolbachian clade within the Ecdysozoa.
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Interaction of Neisseria meningitidis with Human Meningeal Cells Induces the Secretion of a Distinct Group of Chemotactic, Proinflammatory, and Growth-Factor Cytokines
TLDR
The data demonstrate that cells of the leptomeninges are not inert but are active participants in the innate host response during lePTomeningitis and that there is a complex relationship between expression of meningococcal components and cytokine induction.
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A worm's best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi
TLDR
Data offer strong support for the hypothesis that Wolbachia confers longevity on O. ochengi through a defensive mutualism, which diverts a potentially lethal effector cell response.
View on Royal Society
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