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Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Metal ions are essential cofactors for a wealth of biological processes, including oxidative phosphorylation, gene regulation and free-radical homeostasis. Failure to maintain appropriate levels ofExpand
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A family of mammalian Na+-dependent L-ascorbic acid transporters
Vitamin C (L-ascorbic acid) is essential for many enzymatic reactions, in which it serves to maintain prosthetic metal ions in their reduced forms (for example, Fe2+, Cu+),, and for scavenging freeExpand
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Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functionalExpand
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A Novel System A Isoform Mediating Na+/Neutral Amino Acid Cotransport*
A cDNA clone encoding a plasma membrane alanine-preferring transporter (SAT2) has been isolated from glutamatergic neurons in culture and represents the second member of the system A family ofExpand
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Identification of Mammalian Proline Transporter SIT1 (SLC6A20) with Characteristics of Classical System Imino*
Amino acid homeostasis depends on specific amino acid transport systems, many of which have been characterized at the molecular level. However, the classical System IMINO, defined as theExpand
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Functional Properties and Cellular Distribution of the System A Glutamine Transporter SNAT1 Support Specialized Roles in Central Neurons*
Glutamine, the preferred precursor for neurotransmitter glutamate and GABA, is likely to be the principal substrate for the neuronal System A transporter SNAT1 in vivo. We explored the functionalExpand
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Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1).
DMT1 (divalent metal-ion transporter 1) is a widely expressed metal-ion transporter that is vital for intestinal iron absorption and iron utilization by most cell types throughout the body, includingExpand
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Human vitamin C (L-ascorbic acid) transporter SVCT1.
In human, vitamin C (l-ascorbic acid) is an essential micronutrient required for an array of biological functions including enzymatic reactions and antioxidation. We describe here the molecularExpand
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Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1*
Background: DMT1 plays essential roles in iron homeostasis, but questions remain about which other metals this transporter serves. Results: DMT1 exhibits substrate selectivity Cd2+ > Fe2+ > Co2+,Expand
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Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain.
The SLC6 gene family comprises membrane proteins that transport neurotransmitters, amino acids, or osmolytes. We report the first functional characterization of the human SLC6A15 gene, which codesExpand
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