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Deletion of the Aspergillus flavus Orthologue of A. nidulans fluG Reduces Conidiation and Promotes Production of Sclerotia but Does Not Abolish Aflatoxin Biosynthesis
TLDR
The results suggest that the function of fluG and the signaling pathways related to conidiation are different in the two related aspergilli.
NsdC and NsdD Affect Aspergillus flavus Morphogenesis and Aflatoxin Production
TLDR
The results suggest that NsdC and NsdD regulate transcription of genes required for early processes in conidiophore development preceding conidium formation, and support previous studies showing that there is a strong association between conidiophileophore and sclerotium development and aflatoxin production in A. flavus.
Genomic sequence of the aflatoxigenic filamentous fungus Aspergillus nomius
TLDR
This study provides a preliminary analysis of the A. nomius genome and finds that this genome sequence provides an additional evolutionary reference point for studying the genetics and biology of aflatoxigenic species production.
Draft Genome Sequence of an Aflatoxigenic Aspergillus Species, A. bombycis
TLDR
The genome of the A. bombycis Type strain was sequenced and found it to be comparable in size and in numbers of predicted genes to other sequenced Aspergilli, and showed that this species is likely heterothallic (self-infertile) and contains a single MAT1-2 gene.
Comparison of Expression of Secondary Metabolite Biosynthesis Cluster Genes in Aspergillus flavus, A. parasiticus, and A. oryzae
TLDR
RNA-seq is used to compare expression of secondary metabolite genes in gene clusters for the closely related fungi A. parasiticus, A. oryzae, and A. flavus S and L sclerotial morphotypes to refine the identification of probable functional gene clusters within these species.
The Aspergillus flavus Homeobox Gene, hbx1, Is Required for Development and Aflatoxin Production
TLDR
The results demonstrate that hbx1 not only plays a significant role in controlling A. flavus development but is also critical for the production of secondary metabolites, such as aflatoxins.
Transcriptome Analysis of Aspergillus flavus Reveals veA-Dependent Regulation of Secondary Metabolite Gene Clusters, Including the Novel Aflavarin Cluster
TLDR
The present transcriptome study shows that veA is necessary for the expression of a large number of genes, and predicts that cluster 39 is responsible for the production of aflavarin.
Association with AflR in Endosomes Reveals New Functions for AflJ in Aflatoxin Biosynthesis
TLDR
Aflatoxins are the most potent naturally occurring carcinogens of fungal origin and AflJ is proposed to act as a transcriptional co-activator, thus controlling the availability of AflR for transcriptional activation of aflatoxin biosynthesis cluster genes.
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