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Genotoxicity of fluoroquinolines and methylquinolines.
TLDR
Structural-activity studies indicate that positions 1-3 in quinoline are critical sites associated with its genotoxicity.
Genotoxicity of carcinogens in human hepatocytes: application in hazard assessment.
TLDR
These studies provide additional support for the use of human hepatocytes in a DNA repair test in the investigation of genotoxicity, as the induction of DNA repair by DNA-reactive carcinogens of several structural classes and related noncarcinogens was studied.
Study of potential in vitro and in vivo genotoxicity in hepatocytes of quinolone antibiotics.
TLDR
The findings suggest that ciprofloxacin is not DNA reactive, but it induces in vitro UDS as a consequence of some indirect action, which could be linked to the genotoxicity of quinolone antibiotics.
Evaluation of secondary nitroalkanes, their nitronates, primary nitroalkanes, nitrocarbinols, and other aliphatic nitro compounds in the Ames Salmonella assay.
TLDR
Positive Salmonella mutation data for the nitronates of the secondary nitroalkanes studied correlate very well with the very slow rate of reprotonation of secondary Nitroalkane nitronate at pH 7.7, and provide further evidence that nitronsates of secondary nitromates, rather than the neutral parent forms with which they may be in equilibrium, are the more proximate mutagenic species.
Biotransformation of aromatic amines to DNA-damaging products by urinary bladder organ cultures.
TLDR
Results indicate that rabbit urinary bladder has the ability to biotransform aromatic amines to DNA-damaging products and has the capacity to repair damaged DNA.
Sex and strain differences in the hepatocyte primary culture/DNA repair test
TLDR
Results demonstrate that both the strain and the sex of the animal used as a source of hepatocytes can affect the HPC/DNA repair test.
Mutagenicity of hydralazine in mammalian cells and bacteria.
TLDR
The genotoxicity of hydralazine (HDZ), an antihypertensive agent, was evaluated in mammalian cells and bacteria and the first evidence of the mutagenicity of HDZ in mammals cells is provided.
Extracellular metabolites of 2-aminofluorene in cultures of rapid and slow acetylator rabbit hepatocytes as a model for urinary and biliary metabolism.
TLDR
Results indicate that hepatocytes from both acetylator phenotypes have similar capacities to excrete N-hydroxy-2-AAF and to detoxify the parent aromatic amine, which can be related to the carcinogenicity of 2-AF in either phenotype.