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Effects of Yersinia enterocolitica O:3 Derivatives on B Lymphocyte Activation In Vivo
Results suggest that SPF Swiss mice inoculated with any one of the Y. enterocolitica O:3 derivatives tested exhibited polyclonal activation of B lymphocytes as a result of stimulation by various bacterial components and not only LPS stimulation. Expand
TNF-α, H2O2 and NO response of peritoneal macrophages to Yersinia enterocolitica O:3 derivatives
The results indicate the possibility that in vivo Yops may aid the evasion of the bacteria from the host defense mechanism by impairing the secretion of NO by macrophages. Expand
Role of Yersinia pseudotuberculosis outer proteins (Yops) in murine humoral immune response
The infection of mice with the wild-type (WT) strain of Y. pseudotuberculosis did not induce polyclonal activation of B lymphocytes. Suppression in the production of certain isotypes of Ig wasExpand
Pattern of Macrophage Activation in Yersinia‐Resistant and Yersinia‐Susceptible Strains of Mice
The results suggest that Y. enterocolitica infection leads to the modulation of M1 macrophage in C57Bl/6 mice, and M2 macrophages in BALB/c mice. Expand
Production of Autoantibodies Associated with Polyclonal Activation in Yersinia enterocolitica O:8‐Infected Mice
It was concluded that infection of mice with either the virulent strain of Y. enterocolitica O:8 or with its plasmidless isogenic pair resulted in the polyclonal activation of the splenic B lymphocytes including some autoreactive clones. Expand
Association between polyclonal B cell activation and the presence of autoantibodies in mice infected with Yersinia enterocolitica O:3.
It is demonstrated that Y. enterocolitica O:3 infection induces polyclonal activation of murine B cells which is correlated with the activation of some autoreactive lymphocyte clones and an increase of anti-myosin and anti- myelin immunoglobulins. Expand
Polyclonal activation as a consequence of infection of mice with Yersinia enterocolitica O:3 isolated from patients with or without arthritis.
It was observed polyclonal activation of B-lymphocytes with all the bacterial strains tested. The IgG2a and IgG3 isotypes were that which present the major activation. The three bacterial strainsExpand
Invasin of Yersinia pseudotuberculosis is not a polyclonal activator of mouse B lymphocytes
Department of Biological Sciences School of Pharmaceutical Sciences Sao Paulo State University, UNESP, Araraquara, SP is presented for the first time in a major conference of the Brazilian Academy of Sciences on drug discovery and development. Expand
Polyclonal B-cell activation in mice infected by intragastric route with Yersinia enterocolitica O:8.
The infection of mice with virulent and avirulent strains of Y. enterocolitica O: 8 resulted in polyclonal activation of the repertory of spleen and Peyer’s patches B lymphocytes, including someExpand