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Drug Liposome Partitioning as a Tool for the Prediction of Human Passive Intestinal Absorption
Liposome distribution coefficients of ionizable drugs derived by a pH-metric titration were successfully used to calculate a parameter that correlates with the percentage of passive intestinal absorption in humans.
Dissolution Rate Enhancement by in Situ Micronization of Poorly Water-Soluble Drugs
Evaluating a novel in situ micronization method avoiding any milling techniques to produce nano- or microsized drug particles by controlled crystallization to enhance the dissolution rate of poorly water-soluble drugs found it suitable for the production of micro-sized drugs.
Ibuprofen crystals with optimized properties.
The improvement of the substance characteristics of ibuprofen is reached by changes in the outer appearance of the crystals and in surface modifications.
Micron‐Size Drug Particles: Common and Novel Micronization Techniques
  • N. Rasenack, B. Müller
  • Materials Science, Medicine
    Pharmaceutical development and technology
  • 1 January 2004
Common and novel techniques for the production of a drug in small particle size are summarized and the properties of the resulting products that are obtained by different techniques are characterized and compared.
Increasing drug solubility by means of bile salt-phosphatidylcholine-based mixed micelles.
  • M. Hammad, B. Müller
  • Chemistry, Medicine
    European journal of pharmaceutics and…
  • 1 November 1998
Study of the solubilization of commercial grades of soya phosphatidylcholine (SPC) with different purities by bile salts (BS) indicated that only highly pure grades of SPC are suitable for the
Partial solubility parameters of poly(D,L-lactide-co-glycolide).
Although the turbidity titration method was found to be the most precise, it was not possible to sufficiently explain the differences between three polymer batches during microparticle production.
Colloidal carriers for intravenous drug targeting: Plasma protein adsorption patterns on surface‐modified latex particles evaluated by two‐dimensional polyacrylamide gel electrophoresis
The correlation between adsorbed proteins and carrier behavior in vivo was not valid for all of the analyzed protein species, which proves that it is insufficient to look only at physico‐chemical data to predict organ distribution.
Aerosol solvent extraction system : a new microparticle production technique
Abstract The aerosol solvent extraction system (ASES) utilises the extraction properties of supercritical gases for the production of microparticles. Extraction with supercritical gases is frequently
Application of aerosol solvent extraction system (ASES) process for preparation of liposomes in a dry and reconstitutable form.
The entrapment efficiency of hydrated MCZ microparticles was improved by increasing the pH of the hydration medium, and the percentage of drug recovered was increased with an increase of the drug concentration in the spraying solution.
In vitro evaluation of dry powder inhalers II: influence of carrier particle size and concentration on in vitro deposition
Dry powders and their delivery devices are an alternative to pressurized metered-dose inhalers (pMDI) for the administration of aerosols to the lungs. Generally dry powder aerosols are formulated by