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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Alzheimer's disease1 is characterized by a widespread functional disturbance of the human brain. Fibrillar amyloid proteins are deposited inside neurons as neurofibrillary tangles2 andExpand
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The three operators of the lac operon cooperate in repression.
We tested the effect of systematic destruction of all three lac operators of the chromosomal lac operon of Escherichia coli on repression by Lac repressor. Absence of just one ‘pseudo‐operator’ O2 orExpand
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Quality and position of the three lac operators of E. coli define efficiency of repression.
Repression of the lac promoter may be achieved in two different ways: either by interference with the action of RNA polymerase or by interference with CAP activation. We investigated cooperativeExpand
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Repression oflacPromoter as a Function of Distance, Phase and Quality of an AuxiliarylacOperator
The tetrameric Lac repressor can bind simultaneously to twolacoperators on the same DNA molecule, thereby including the formation of a DNA loop. We investigated the phasing dependence of DNA loopExpand
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Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator.
The tetrameric Lac repressor can bind simultaneously to two lac operators on the same DNA molecule, thereby including the formation of a DNA loop. We investigated the phasing dependence of DNA loopExpand
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Genetic Studies of Lac Repressor: 4000 Single Amino Acid Substitutions and Analysis of the Resulting Phenotypes on the Basis of the Protein Structure
TLDR
Each amino acid from position 2 to 329 of Lac repressor was replaced by 12 or 13 of the 20 natural occurring amino acids. Expand
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The lac Operon: A Short History of a Genetic Paradigm
A description of the history and present knowledge of a paradigmatic system, the lac operon of Escherichia coli. A unique combination of personal anecdotes and present-day science makes this bookExpand
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lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.
Tetrameric lac repressor may bind to two lac operators on one DNA fragment and induce the intervening DNA to form a loop. Electron microscopy, non‐denaturing polyacrylamide gel electrophoresis, andExpand
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Four dimers of λ repressor bound to two suitably spaced pairs of λ operators form octamers and DNA loops over large distances
Abstract Transcription factors that are bound specifically to DNA often interact with each other over thousands of base pairs [1,2]. Large DNA loops resulting from such interactions have beenExpand
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How AraC interacts specifically with its target DNAs.
Previous work indicates that one subunit of the AraC protein dimer binds to a DNA target araI1, of 17 base-pairs. We systematically substituted every base-pair in a synthetic araI1 target with theExpand
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