• Publications
  • Influence
Pten Regulates Neuronal Arborization and Social Interaction in Mice
CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN mutations inExpand
  • 783
  • 57
Brain-Derived Neurotrophic Factor Conditional Knockouts Show Gender Differences in Depression-Related Behaviors
BACKGROUND Indirect evidence suggests that loss of brain-derived neurotrophic factor (BDNF) from forebrain regions contributes to an individual's vulnerability for depression, whereas upregulation ofExpand
  • 438
  • 19
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus
Newborn neurons in the dentate gyrus of the adult hippocampus rely upon cAMP response element binding protein (CREB) signaling for their differentiation into mature granule cells and theirExpand
  • 353
  • 12
  • PDF
Conditional Deletion of TrkB but Not BDNF Prevents Epileptogenesis in the Kindling Model
Epileptogenesis is the process whereby a normal brain becomes epileptic. We hypothesized that the neurotrophin brain-derived neurotrophic factor (BDNF) activates its receptor, TrkB, in theExpand
  • 280
  • 10
TrkB Has a Cell-Autonomous Role in the Establishment of Hippocampal Schaffer Collateral Synapses
Neurotrophin signaling has been implicated in the processes of synapse formation and plasticity. To gain additional insight into the mechanism of BDNF and TrkB influence on synapse formation andExpand
  • 150
  • 10
  • PDF
Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells
Some cases of autism spectrum disorder have mutations in the lipid phosphatase, phosphatase and tensin homolog on chromosome 10 (Pten). Tissue specific deletion of Pten in the hippocampus and cortexExpand
  • 113
  • 10
  • PDF
DREADDS: Use and application in behavioral neuroscience.
Technological advances over the last decade are changing the face of behavioral neuroscience research. Here we review recent work on the use of one such transformative tool in behavioral neuroscienceExpand
  • 115
  • 9
  • PDF
Neurotrophin-Dependent Dendritic Filopodial Motility: A Convergence on PI3K Signaling
Synapse formation requires contact between dendrites and axons. Although this process is often viewed as axon mediated, dendritic filopodia may be actively involved in mediating synaptogenic contact.Expand
  • 100
  • 8
  • PDF
miR-132 Mediates the Integration of Newborn Neurons into the Adult Dentate Gyrus
Neuronal activity enhances the elaboration of newborn neurons as they integrate into the synaptic circuitry of the adult brain. The role microRNAs play in the transduction of neuronal activity intoExpand
  • 120
  • 8
  • PDF