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Glycyrrhizic acid inhibits virus growth and inactivates virus particles
TLDR
It is reported that this drug inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate, and inactivates herpes simplex virus particles irreversibly.
In vitro Inhibition of Infectivity of Polio Viruses by Guanidine
TLDR
This investigation investigated whether some simple guanidine derivatives may reduce the infectivity of viruses for cultured mammalian cells by boiling chemicals dissolved in water and adding to the culture media.
The mechanism of guanidine inhibition of poliovirus growth in vitro.
Abstract Guanidine inhibits both the replication of poliovirus RNA and the appearance in infected cells of an active RNA polymerase, without affecting the overall synthesis of virus-coded proteins.
Selective inhibition of poliovirus growth by d-Penicillamine in vitro.
TLDR
D -Penicillamine inhibits poliovirus growth in vitro and shows no inhibitory effect against herpes simplex, vaccinia, and vesicular stomatitis viruses and is ineffective as an antiviral agent.
Effect of 5-iodo-2′-deoxyuridine on Vaccinia Virus, in vitro
TLDR
Five halogenated pyrimidines inhibit the biosynthesis of deoxyribonucleic acid by competing with thymidine in the synthesis of DNA-thymazine in mouse Ehrlich ascite cells.
Antiviral activity of glycyrrhizic acid
Glycyrrhizic acid inhibits the growth of several DNA and RNA viruses in cell cultures and inactivates Herpes simplex 1 virus irreversibly.
Viral synthesis after simultaneous infection with guanidine-sensitive and guanidine-dependent polioviruses.
TLDR
This phenomenon of rescue seems not to be due to an “exchange” of RNA polymerases but, more probably, to a different “affinity’ of virus genomes for inhibitors.
Potentiating Effect of 5-Fluorouracil on the in vitro Antipoliovirus Activity of Guanidine
TLDR
This work has shown the ability of guanidine to stop the cytotoxic effect of poliovirus even when added to cell cultures which were infected several hours previously.
Specific inhibition of poliovirus induced blockade of cell protein synthesis by a thiopyrimidine derivative.
Summary A thiopyrimidine derivative, i.e. ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate (S-7) is capable of preventing both poliovirus RNA synthesis and virus induced inhibition of cell
SPECIFIC INHIBITION OF VIRUS MULTIPLICATION BY BICHLORINATED PYRIMIDINES *
TLDR
Dichloropyrimidines inhibit the growth of unrelated R N A and DNA viruses, such as polio 1, coxsackie BI, vaccinia and herpes simplex viruses, while being inactive against vesicular stomatitis virus and Newcastle disease virus.
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