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Targeting VEGF/VEGFR to Modulate Antitumor Immunity
In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase theExpand
CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients
  • S. Su, B. Hu, +13 authors B. Liu
  • Biology, Medicine
  • Scientific reports
  • 28 January 2016
Strategies that enhance the function of T cells are critical for immunotherapy. One negative regulator of T-cell activity is ligand PD-L1, which is expressed on dentritic cells (DCs) or some tumorExpand
10-Hydroxycamptothecin loaded nanoparticles: preparation and antitumor activity in mice.
10-Hydroxycamptothecin (HCPT) loaded nanoparticles made from poly(caprolactone-co-lactide)-b-PEG-b-poly(caprolactone-co-lactide) (PCLLA-PEG-PCLLA) block copolymer, were prepared by a novel two-stepExpand
Superior antitumor efficiency of cisplatin-loaded nanoparticles by intratumoral delivery with decreased tumor metabolism rate.
cis-Dichlorodiamminoplatinum (II) (cisplatin) has demonstrated extraordinary activities against a variety of solid tumors. However, the clinical efficacy is contrasted by its toxicity profile. ToExpand
Preparation and evaluation of PEG-PCL nanoparticles for local tetradrine delivery.
To establish a satisfactory delivery system for local delivery of Tetradrine (Tet), four kinds of core-shell nanoparticles were prepared from di-block copolymer of methoxy poly(ethyleneExpand
Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions
BackgroundCirculating cell-free microRNAs have been identified as potential cancer biomarkers. However, the existence and the potential application of cell-free miRNAs in effusion samples are stillExpand
Cell-Free MicroRNA Expression Profiles in Malignant Effusion Associated with Patient Survival in Non-Small Cell Lung Cancer
Objective MicroRNAs (miRNAs) expression is altered in cancer cells, and miRNAs could serve as diagnostic and prognostic biomarker for cancer patients. This study was designed to analyze circulatingExpand
TAZ Is Highly Expressed in Gastric Signet Ring Cell Carcinoma
Transcriptional coactivator with PDZ-binding motif (TAZ) is known to bind to a variety of transcription factors to control cell differentiation and organ development. We examined TAZ protein levelsExpand
Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells.
OBJECTIVE Chemoresistance is a major obstacle to successful cancer chemotherapy. In this study, we examined the ability of gambogic acid (GA) to reverse docetaxel resistance in BGC-823/Doc gastricExpand
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