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Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report,Expand
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The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota.
Breast-fed infant microbiota is typically rich in bifidobacteria. Herein, major human milk oligosaccharides (HMOS) are assessed for their ability to promote the growth of bifidobacteria and toExpand
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Effects of transient bottom water currents and oxygen concentrations on benthic exchange rates as assessed by eddy correlation measurements
[1] Eddy correlation (EC) measurements in the benthic boundary layer (BBL) allow estimating benthic O2 uptake from a point distant to the sediment surface. This noninvasive approach has clearExpand
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Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex.
The Hippo pathway controls organ size and tissue homeostasis through a kinase cascade leading from the Ste20-like kinase Hpo (MST1/2 in mammals) to the transcriptional coactivator Yki (YAP/TAZ inExpand
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CdS nanocrystal-based electrochemiluminescence biosensor for the detection of low-density lipoprotein by increasing sensitivity with gold nanoparticle amplification.
Mercaptoacetic acid (RSH)-capped CdS nanocrystals (NCs) was demonstrated to be electrochemically reduced during potential scan and react with the coreactant S2O8(2-) to generate strongExpand
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Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice haveExpand
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Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as byExpand
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Control of sulphate and methane distributions in marine sediments by organic matter reactivity
Abstract The reactivity of organic matter serving as fuel for microbial activity in buried sedimentary layers imposes a strong control on the subsurface biogeochemical zonation and rates ofExpand
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Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market. Protein kinase inhibition also has significant potential for aExpand
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High-performance polymer semiconducting heterostructure devices by nitrene-mediated photocrosslinking of alkyl side chains.
Heterostructures are central to the efficient manipulation of charge carriers, excitons and photons for high-performance semiconductor devices. Although these can be formed by stepwise evaporation ofExpand
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