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Retrosynthetic Reaction Prediction Using Neural Sequence-to-Sequence Models
TLDR
A fully data driven model that learns to perform a retrosynthetic reaction prediction task, which is treated as a sequence-to-sequence mapping problem, and also overcomes certain limitations associated with rule-based expert systems and with any machine learning approach that contains a rule- based expert system component. Expand
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.
TLDR
A model in which the HBXIP/Hotair/LSD1 complex serves as a critical effector of c- myc in activating transcription of its target genes is supported, illuminating long-standing questions on how c-Myc drives carcinogenesis. Expand
Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.
TLDR
It is concluded that TNF-α promotes the growth of breast cancer through the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1. Expand
Enhanced spectral breathing for sub-25 fs pulse generation in a Yb-fiber laser.
TLDR
A dispersion-mapped Yb-fiber laser with enhanced intracavity spectral breathing is demonstrated with transform-limited narrow bandwidth seed pulse for the amplifier fiber and spectral scaling is achieved by single mode fiber. Expand
Efficient and reusable polyamide-56 nanofiber/nets membrane with bimodal structures for air filtration.
TLDR
The successful synthesis of PA-56 NFN medium would not only make it a promising candidate for air filtration, but also provide new insights into the design and development of nanonet-based bimodal structures for various applications. Expand
Self-similar evolution in a short fiber amplifier through nonlinear pulse preshaping.
We report on a nonlinear preshaper that optimizes initial pulses for self-similar evolution in a next fiber amplifier. It consists of a pair of gratings and a segment of single-mode fiber (SMF). TheExpand
Preoperative serum lipids as prognostic predictors in esophageal squamous cell carcinoma patients with esophagectomy
TLDR
It is indicated that preoperative serum total cholesterol and low-density lipoprotein cholesterol are prognostic factors for esophageal squamous cell carcinoma patients who underwent esophagectomy and LHR can serve as a promising serum lipids-based prognostic indicator. Expand
Inhibition of listeriolysin O oligomerization by lutein prevents Listeria monocytogenes infection.
TLDR
Lutein, a natural small molecule existing widely in fruits and vegetables, is demonstrated as an effective inhibitor of LLO that works by blocking its oligomerization during invasion without showing significant bacteriostatic activity. Expand
MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability
TLDR
It is demonstrated that MSIsensor-pro is an ultrafast, accurate, and robust MSI calling method that significantly outperformed the current leading methods in both accuracy and computational cost. Expand
The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer.
TLDR
It is concluded that HBXIP up-regulates YAP expression via activating transcription factor c-Myb to facilitate the growth of hepatoma cells and provides new insights into the mechanism of YAP regulation. Expand
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