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- Publications
- Influence
Complete Replication of Hepatitis C Virus in Cell Culture
- B. Lindenbach, M. Evans, +8 authors C. Rice
- Biology, Medicine
- Science
- 22 July 2005
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length… Expand
Identification of microRNAs of the herpesvirus family
- S. Pfeffer, A. Sewer, +16 authors T. Tuschl
- Biology, Medicine
- Nature Methods
- 16 February 2005
Epstein-Barr virus (EBV or HHV4), a member of the human herpesvirus (HHV) family, has recently been shown to encode microRNAs (miRNAs). In contrast to most eukaryotic miRNAs, these viral miRNAs do… Expand
Unravelling hepatitis C virus replication from genome to function
- B. Lindenbach, C. Rice
- Biology, Medicine
- Nature
- 17 August 2005
Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to dissect this… Expand
Cellular cofactors affecting hepatitis C virus infection and replication
- G. Randall, M. Panis, +17 authors C. Rice
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 31 July 2007
Recently identified hepatitis C virus (HCV) isolates that are infectious in cell culture provide a genetic system to evaluate the significance of virus–host interactions for HCV replication. We have… Expand
Structural Insights into RNA Recognition by RIG-I
- Dahai Luo, S. Ding, A. Vela, Andrew S. Kohlway, B. Lindenbach, A. Pyle
- Biology, Medicine
- Cell
- 14 October 2011
Intracellular RIG-I-like receptors (RLRs, including RIG-I, MDA-5, and LGP2) recognize viral RNAs as pathogen-associated molecular patterns (PAMPs) and initiate an antiviral immune response. To… Expand
Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry
- Donna M. Tscherne, C. T. Jones, M. Evans, B. Lindenbach, J. McKeating, C. Rice
- Biology, Medicine
- Journal of Virology
- 15 February 2006
ABSTRACT Hepatitis C virus (HCV) is an important human pathogen associated with chronic liver disease. Recently, based on a genotype 2a isolate, tissue culture systems supporting complete replication… Expand
Genetic Interaction of Flavivirus Nonstructural Proteins NS1 and NS4A as a Determinant of Replicase Function
- B. Lindenbach, C. Rice
- Biology, Medicine
- Journal of Virology
- 1 June 1999
ABSTRACT Nonstructural protein 1 (NS1) of yellow fever virus (YF) is a glycoprotein localized to extracytoplasmic compartments within infected cells. We have previously shown that NS1 can be supplied… Expand
The ins and outs of hepatitis C virus entry and assembly
- B. Lindenbach, C. Rice
- Biology, Medicine
- Nature Reviews Microbiology
- 1 October 2013
Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process… Expand
A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication.
- P. Bredenbeek, E. A. Kooi, B. Lindenbach, N. Huijkman, C. Rice, W. Spaan
- Biology, Medicine
- The Journal of general virology
- 1 May 2003
Yellow fever virus (YF) is the prototype member of the Flavivirus genus. Here, we report the successful construction of a full-length infectious cDNA clone of the vaccine strain YF-17D. YF cDNA was… Expand