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The transcription factor PLZF directs the effector program of the NKT cell lineage.
The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family ofExpand
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IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis
Polymorphisms attenuating IL-10 signaling confer genetic risk for inflammatory bowel disease. Yet how IL-10 prevents mucosal autoinflammation is incompletely understood. We demonstrate usingExpand
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Accelerated rejection of Fas ligand-expressing heart grafts.
The Fas/Fas ligand (FasL) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses. Recently, there has been renewedExpand
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CD4+CD25+ Foxp3+ Regulatory T Cells Protect against T Cell-Mediated Fulminant Hepatitis in a TGF-β-Dependent Manner in Mice1
Regulatory T cells (Tregs), which are characterized by expression of CD4, CD25, and Foxp3, play a crucial role in the control of immune responses to both self and non-self Ags. To date, there areExpand
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IL-10 modulates DSS-induced colitis through a macrophage – ROS – NO axis
Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis. Interleukin-10 (IL-10) is a critical regulator of this, yet its cellular targets and mechanisms ofExpand
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Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
While the molecular mechanisms promoting activation of the Nod-like Receptor (NLR) family member NLRP3 inflammasome are beginning to be defined, little is known about the mechanisms that regulate theExpand
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Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling
Objective Macrophage interleukin (IL)-10 signalling plays a critical role in the maintenance of a regulatory phenotype that prevents the development of IBD. We have previously found that anti-tumourExpand
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Pharmacological Inhibitors of the NLRP3 Inflammasome
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. ByExpand
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Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis
The fate of Foxp3+ regulatory T (Treg) cells responding during autoimmunity is not well defined. We observed a marked elevation in KLRG1+ (where KLRG1 stands for killer cell lectin‐like receptor G1)Expand
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IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense againstExpand
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