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- Publications
- Influence
The transcription factor PLZF directs the effector program of the NKT cell lineage.
- A. Savage, Michael G Constantinides, +5 authors A. Bendelac
- Biology, Medicine
- Immunity
- 19 September 2008
The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of… Expand
IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis
- B. Li, Prajwal Gurung, R. K. Subbarao Malireddi, P. Vogel, T. Kanneganti, T. Geiger
- Biology, Medicine
- Nature communications
- 19 December 2014
Polymorphisms attenuating IL-10 signaling confer genetic risk for inflammatory bowel disease. Yet how IL-10 prevents mucosal autoinflammation is incompletely understood. We demonstrate using… Expand
Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
- Prajwal Gurung, B. Li, R. K. Subbarao Malireddi, M. Lamkanfi, T. Geiger, T. Kanneganti
- Biology, Medicine
- Scientific reports
- 28 September 2015
While the molecular mechanisms promoting activation of the Nod-like Receptor (NLR) family member NLRP3 inflammasome are beginning to be defined, little is known about the mechanisms that regulate the… Expand
Accelerated rejection of Fas ligand-expressing heart grafts.
- T. Takeuchi, T. Ueki, +8 authors T. Kitamura
- Medicine
- Journal of immunology
- 1999
The Fas/Fas ligand (FasL) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses. Recently, there has been renewed… Expand
CD4+CD25+ Foxp3+ Regulatory T Cells Protect against T Cell-Mediated Fulminant Hepatitis in a TGF-β-Dependent Manner in Mice1
Regulatory T cells (Tregs), which are characterized by expression of CD4, CD25, and Foxp3, play a crucial role in the control of immune responses to both self and non-self Ags. To date, there are… Expand
IL-10 modulates DSS-induced colitis through a macrophage – ROS – NO axis
- B. Li, Rajshekhar Alli, P. Vogel, T. Geiger
- Biology, Medicine
- Mucosal Immunology
- 1 May 2013
Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis. Interleukin-10 (IL-10) is a critical regulator of this, yet its cellular targets and mechanisms of… Expand
Pharmacological Inhibitors of the NLRP3 Inflammasome
- A. Zahid, B. Li, Arnaud John Kombe Kombe, T. Jin, Jin-Hui Tao
- Chemistry, Medicine
- Front. Immunol.
- 25 October 2019
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. By… Expand
Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling
- P. Koelink, F. Bloemendaal, +14 authors G. R. van den Brink
- Medicine
- Gut
- 10 September 2019
Objective Macrophage interleukin (IL)-10 signalling plays a critical role in the maintenance of a regulatory phenotype that prevents the development of IBD. We have previously found that anti-tumour… Expand
Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis
The fate of Foxp3+ regulatory T (Treg) cells responding during autoimmunity is not well defined. We observed a marked elevation in KLRG1+ (where KLRG1 stands for killer cell lectin‐like receptor G1)… Expand
IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against… Expand