• Publications
  • Influence
The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction
Wnt signalling is required for neural crest (NC) induction; however, the direct targets of the Wnt pathway during NC induction remain unknown. We show here that the homeobox gene Gbx2 is essential inExpand
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Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells
Tumor progression involves the ability of cancer cells to communicate with each other and with neighboring normal cells in their microenvironment. Microvesicles (MV) derived from human cancer cellsExpand
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  • Open Access
Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis.
RATIONALE Lung fibroblasts are key mediators of fibrosis resulting in accumulation of excessive interstitial collagen and extracellular matrix, but their origins are not well defined. OBJECTIVES WeExpand
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IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma1
IL-17 is a pivotal proinflammatory molecule in asthmatics. However, the cellular source of IL-17 in asthma has not been identified to date. In this study, we report that macrophages rather than Th17Expand
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Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice
Previous data demonstrate that traumatic brain injury (TBI) activates autophagy, and increases microtubule-associated protein 1 light chain 3 (LC3) immunostaining mainly in neurons. However, the roleExpand
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A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.
X-linked nephrogenic diabetes insipidus (XNDI) is a severe kidney disease caused by inactivating mutations in the V2 vasopressin receptor (V2R) gene that result in the loss of renalExpand
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  • Open Access
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.
One of the hallmarks of type 2 diabetes is that pancreatic beta cells fail to release sufficient amounts of insulin in the presence of elevated blood glucose levels. Insulin secretion is modulated byExpand
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ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.
Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-overexpressingExpand
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HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.
UNLABELLED Two hallmarks of clear-cell renal cell carcinoma (ccRCC) are constitutive hypoxia-inducible factor (HIF) signaling and abundant intracellular lipid droplets (LD). However, regulation ofExpand
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Tyrosine phosphorylation of protein kinase complex BAK1/BIK1 mediates Arabidopsis innate immunity
  • W. Lin, B. Li, +4 authors L. Shan
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 14 February 2014
Significance The innate immune response is initiated by the recognition of conserved microbial signatures via membrane-resident receptor complex. The dimerization and phosphorylation of ArabidopsisExpand
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  • Open Access