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Deacetylase inhibition promotes the generation and function of regulatory T cells
Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression as well as the functions of more than 50 transcription factors and nonhistone proteins. We found that… Expand
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.
Regulatory T (Treg) cells suppress inflammatory immune responses and autoimmunity caused by self-reactive T cells. The key Treg cell transcription factor Foxp3 is downregulated during inflammation to… Expand
S-Nitrosylation from GSNOR Deficiency Impairs DNA Repair and Promotes Hepatocarcinogenesis
- W. Wei, B. Li, M. Hanes, S. Kakar, X. Chen, L. Liu
- Biology, Medicine
- Science Translational Medicine
- 17 February 2010
A reductase that removes harmful nitrosyl groups from cellular proteins guards against liver cancer, perhaps in part by ensuring the health of a crucial DNA repair enzyme. Saying NO to Liver Cancer… Expand
MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway
Recent studies have identified a class of small non‐coding RNA molecules, named microRNA (miRNA), that is dysregulated in malignant brain glioblastoma. Substantial data have indicated that miRNA‐16… Expand
Development of a hybrid proximal sensing method for rapid identification of petroleum contaminated soils.
- Somsubhra Chakraborty, D. Weindorf, +4 authors Md Nasim Ali
- Environmental Science, Medicine
- The Science of the total environment
- 1 May 2015
UNLABELLED Using 108 petroleum contaminated soil samples, this pilot study proposed a new analytical approach of combining visible near-infrared diffuse reflectance spectroscopy (VisNIR DRS) and… Expand
The origin and in vivo significance of murine and human culture-expanded endothelial progenitor cells.
- E. E. Sharpe, Amylynn A. Teleron, +4 authors P. Young
- Biology, Medicine
- The American journal of pathology
- 1 May 2006
In adults highly purified populations of early hematopoietic progenitors or cells derived from ex vivo expanded unmobilized human peripheral blood mononuclear cells contribute to new blood vessel… Expand
Targeting NF-κB signaling pathway suppresses tumor growth, angiogenesis, and metastasis of human esophageal cancer
Esophageal cancer is the eighth most common malignancy, and one of the leading causes of cancer-related deaths worldwide. The overall 5-year survival rate of patients with esophageal cancer remains… Expand
All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus
Background It has been documented all-trans retinoic acid (atRA) promotes the development of TGF-β-induced CD4+Foxp3+ regulatory T cells (iTreg) that play a vital role in the prevention of autoimmune… Expand
4,2',5'-trihydroxy-4'-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages.
- Dong-Sung Lee, B. Li, Nam-Kyung Im, Youn-Chul Kim, G. Jeong
- Chemistry, Medicine
- International immunopharmacology
- 1 May 2013
Dalbergia odorifera T. Chen (Leguminosae) has traditionally been used as an ingredient in East Asian medicines to treat various diseases. In the present study, 4,2',5'-trihydroxy-4'-methoxychalcone… Expand
The Effects of Hematopoietic Growth Factors on Neurite Outgrowth
Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) are initially discovered as the essential hematopoietic growth factors regulating bone marrow stem cell proliferation and… Expand