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Disposition of heroin and its metabolites in heroin-related deaths.
Although many deaths occur annually from heroin intoxication, the presence of heroin has not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid chemical and metabolicExpand
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A fatality involving AH-7921.
A case is presented of a 19-year-old white male who was found dead in bed by a friend. While no anatomic cause of death was observed at autopsy, toxicological analysis of his blood identifiedExpand
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A comprehensive study of the stability of cocaine and its metabolites.
The stability of cocaine (COC) in blood bank blood, postmortem human whole blood, and buffers was evaluated with consideration for the presence of the degradation products, benzoylecgonine (BE) andExpand
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Elimination of cocaine and metabolites in plasma, saliva, and urine following repeated oral administration to human volunteers.
Chronic administration of lipophilic drugs can result in accumulation and prolonged elimination during abstinence. It has been suggested that cocaine and/or metabolites can be detected in saliva andExpand
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Methodologic considerations in the interpretation of postmortem carboxyhemoglobin concentrations.
The interpretation of postmortem carboxyhemoglobin (COHb) concentrations can have major implications even when COHb is not the direct cause of death. Much litigation may hinge on the length of timeExpand
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Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors.
A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and showExpand
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Tissue distribution of ketamine in a mixed drug fatality.
While reports of ketamine abuse are increasing, reports of ketamine deaths and tissue concentrations associated with fatalities are rare. We report here a case of a mixed drug fatality involvingExpand
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Distribution of venlafaxine in three postmortem cases.
Venlafaxine (V) is a second-generation antidepressant approved for use in the United States in 1993. It is a derivative of phenethylamine and is structurally unrelated to first- and otherExpand
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Postmortem stability of benzodiazepines in blood and tissues.
The stability of benzodiazepines in blood and tissues was examined in this study. Specifically, diazepam, chlordiazepoxide, flurazepam, and their desalkyl metabolites were studied over severalExpand
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The role of ethanol in heroin deaths.
The purpose of this study was to evaluate the role of ethanol in deaths due to heroin intoxication. Over a 12 month period, all cases investigated by the Office of the Chief Medical Examiner, StateExpand
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