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Heterotopic Ossification: A Comprehensive Review
This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms, as well as current concepts regarding the mechanistic bases for HO.
Current methods of adipogenic differentiation of mesenchymal stem cells.
The following review will explore the variability in adipogenic differentiation in vitro, specifically in 3T3-L1 and primary MSCs derived from both adipose tissue and bone marrow.
Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification
It is demonstrated that Hypoxia inducible factor-1α (Hif1α), a key mediator of cellular adaptation to hypoxia, is highly expressed and active in three separate mouse models: trauma- induced, genetic, and a hybrid model of genetic and trauma-induced HO.
The Current State of Fat Grafting: A Review of Harvesting, Processing, and Injection Techniques
There has been a substantial increase in research interest to identify methodologies for optimizing fat graft survival, but despite some differences in harvest and implantation technique in the laboratory, these findings have not translated into a universal protocol for fat grafting.
Pierre Robin Sequence and Treacher Collins Hypoplastic Mandible Comparison Using Three-Dimensional Morphometric Analysis
Three-dimensional mandibular morphometric analysis in patients with Pierre Robin sequence and Treacher Collins syndrome revealed distinctly different patterns ofMandibular hypoplasiarelative to normal controls, underscore distinct considerations that must be made in surgical planning for reconstruction.
Concise Review: Adipose‐Derived Stromal Cells for Skeletal Regenerative Medicine
The aim of this review is to define ASCs, to describe the isolation procedure of ASCs, to review the basic biology of their osteogenic differentiation, to discuss cell types and scaffolds available for bone tissue engineering, and to explore imaging of ASCs and their potential future role in human skeletal tissue engineering efforts.
Heterotopic Ossification: Basic-Science Principles and Clinical Correlates.
➤ Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury.➤ The conversion
Treatment of heterotopic ossification through remote ATP hydrolysis
The results suggest that burn injury–exacerbated HO formation can be treated through therapeutics that target burn site ATP hydrolysis and modulation of SMAD1/5/8 phosphorylation and the possibility of multiple therapeutic options for preventing heterotopic ossification in injured patients.
Preclinical Derivation and Imaging of Autologously Transplanted Canine Induced Pluripotent Stem Cells*
The first autologous transplantation of ciPSCs in a large animal model through the generation of canine iPSCs (ciPSCs) from the canine adipose stromal cells and canine fibroblasts of adult mongrel dogs is reported.
Human Adipose Derived Stromal Cells Heal Critical Size Mouse Calvarial Defects
The use of undifferentiated hASCs in the regeneration of a non-healing mouse skeletal defect supports the potential translation for ASC use in the treatment of human skeletal defects.