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The host defense of Drosophila melanogaster.
To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense reactions, many of which are shared with higher organisms. These reactions include the use of physicalExpand
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Truth and Power
Reference EPFL-ARTICLE-223260View record in Web of Science Record created on 2016-11-21, modified on 2016-11-21
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Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila.
Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria onExpand
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Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation.
Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection. Global gene expression analysis of DrosophilaExpand
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Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.
Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response ofExpand
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The Toll and Imd pathways are the major regulators of the immune response in Drosophila
Microarray studies have shown recently that microbial infection leads to extensive changes in the Drosophila gene expression programme. However, little is known about the control of most of the flyExpand
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Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
To identify new Drosophila genes involved in the immune response, we monitored the gene expression profile of adult flies in response to microbial infection by using high-density oligonucleotideExpand
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Morphological and molecular characterization of adult midgut compartmentalization in Drosophila.
Although the gut is a central organ of Eumetazoans and is essential for organismal health, our understanding of its morphological and molecular determinants remains rudimentary. Here, we provide aExpand
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The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection
The Drosophila innate immune system discriminates between pathogens and responds by inducing the expression of specific antimicrobial peptide‐encoding genes through distinct signaling cascades.Expand
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Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia.
The production of antimicrobial peptides is an important aspect of host defense in multicellular organisms. In Drosophila, seven antimicrobial peptides with different spectra of activities areExpand
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