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Protein structure alignment using environmental profiles.
A new protein structure alignment procedure is described. An initial alignment is made by comparing a one-dimensional list of primary, secondary and tertiary structural features (profiles) of twoExpand
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PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity*
We report here syntenic loci in humans and mice incorporating gene clusters coding for secreted proteins each comprising 10 cysteine residues. These conform to three-fingeredExpand
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Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone.
BACKGROUND Antimicrobial drugs that can be taken orally are needed for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Preliminary dataExpand
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NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.
  • T. Bera, S. Das, +6 authors I. Pastan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2 March 2004
We identified a gene (NGEP) that is expressed only in prostate cancer and normal prostate. The two NGEP transcripts are 0.9 kb and 3.5 kb in size and are generated by a differential splicing event.Expand
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Characterization of the B Cell Epitopes Associated with a Truncated Form of Pseudomonas Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients1
Recombinant immunotoxins composed of an Ab Fv fragment joined to a truncated portion of Pseudomonas exotoxin A (termed PE38) have been evaluated in clinical trials for the treatment of various humanExpand
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Rheology of the vitreous body: Part 2. Viscoelasticity of bovine and porcine vitreous.
The viscoelastic properties of the vitreous body from bovine and porcine eyes were determined by microrheometry. Each vitreous sample was sectioned into anterior, central and posterior segments. TheExpand
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POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer
We have identified a gene located on chromosomes 21 that is expressed in normal and neoplastic prostate, and in normal testis, ovary, and placenta. We name this gene POTE (expressed in prostate,Expand
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Human mitochondrial topoisomerase I
Tension generated in the circular mitochondrial genome during replication and transcription points to the need for mtDNA topoisomerase activity. Here we report a 601-aa polypeptide highly homologousExpand
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MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer
Combining a computer-based screening strategy and functional genomics, we previously identified MRP9 (ABCC12), a member of the ATP-binding cassette (ABC) superfamily. We now show that the gene hasExpand
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Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes
  • W. Liu, M. Onda, +4 authors I. Pastan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2 July 2012
Recombinant immunotoxins (RITs) are hybrid proteins used to treat cancer. These proteins are composed of an Fv that reacts with cancer cells joined to a portion of Pseudomonas exotoxin A, which killsExpand
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