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Influence of the pressure field distribution in transcranial ultrasonic neurostimulation.
TLDR
Numerical simulations have shown that the acoustic pattern can be complex inside the rat head and that special care must be taken for small animal studies relating acoustic parameters to neurostimulation effects, especially at a low frequency. Expand
Dynamic Study of Blood–Brain Barrier Closure after its Disruption using Ultrasound: A Quantitative Analysis
TLDR
The model provides an invaluable basis for optimal design and delivery of nanoparticles to the brain and the maximum gap that may be safely generated between endothelial cells and the duration of opening of the BBB is studied. Expand
Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development
TLDR
High throughput gene expression analysis in the cerebellum of a large number of samples of Ts1Cje and euploid mice has revealed a prevailing gene dosage effect on triplicated genes, which strongly suggest that the three-copy genes are directly responsible for the phenotype present in Cerebellum. Expand
Early detection of steatohepatitis in fatty rat liver by using MR elastography.
TLDR
In nonalcoholic fatty rat liver, MR elastography may be useful in the early detection of steatohepatitis by showing increased elasticity and appearing before fibrosis development, which was linked to myofibroblast activation. Expand
MR-guided transcranial brain HIFU in small animal models.
TLDR
Results obtained on rats confirmed that both the MR localization of the US focal point and the pre- and post-HIFU measurement of the tissue stiffness, together with temperature control during HIFU are feasible and valuable techniques for efficient monitoring of HifU in the brain. Expand
MR-guided adaptive focusing of ultrasound
TLDR
This noninvasive technique is shown to accurately correct phase aberrations in a phantom gel with negligible heat deposition and limited acquisition time and demonstrate a major potential in the field of MR-guided ultrasound therapy in particular for transcranial brain high-intensity focused ultrasound. Expand
The variance of quantitative estimates in shear wave imaging: Theory and experiments
TLDR
The shear wave propagation is considered as a deterministic process which is then corrupted during its observation by electronic noise and speckle decorrelation caused by shearing, which indicates that the analytical formulation of the shear modulus variance σμ2 is well suited to understand the parameters' influence in those cases. Expand
Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies
TLDR
A summary of in vivo ultrasound-based strategies shown to deliver drug payloads to tumor environments, to enhance permeability of vessel walls and cell membranes, and to activate drugs and genes in situ are provided. Expand
Ultrasound elastic tensor imaging: comparison with MR diffusion tensor imaging in the myocardium.
TLDR
It is demonstrated that the fiber orientation estimated by ETI, which assesses the shear wave speed (and thus the stiffness), was comparable to that measured by DTi, which evaluates the preferred direction of water diffusion, and have validated this concept within the myocardium. Expand
MR-guided adaptive focusing of therapeutic ultrasound beams in the human head.
TLDR
The proposed energy-based adaptive focusing of ultrasonic waves using magnetic resonance acoustic radiation force imaging (MR-ARFI) in the framework of non-invasive transcranial high intensity focused ultrasound (HIFU) therapy achieves near optimal focusing in an intact human head for the first time. Expand
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