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Advances in organ-on-a-chip engineering
This Review examines how tissue barrier properties, parenchymal tissue function and multi-organ interactions can be recreated in organ-on-a-chip systems and applied for drug screening. Expand
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Hyperbranched glycopolymers for blood biocompatibility.
Carbohydrate-based drug and gene delivery carriers are becoming extremely popular for in vitro and in vivo applications. These carriers are found to be nontoxic and can play a significant role inExpand
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Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections.
Prevention of bacterial colonization and formation of a bacterial biofilm on implant surfaces has been a challenge in orthopaedic surgery. The treatment of implant-associated infections withExpand
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Modulation of complement activation and amplification on nanoparticle surfaces by glycopolymer conformation and chemistry.
The complement system plays an integral part of a host's innate immunity, and its activation is highly dependent on the chemistry and structure of a "foreign" target surface. We determined that theExpand
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Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants
A safe, synthetic anticoagulant-reversal agent based on a dendritic polymer is effective against all the clinical heparin anticoagulants and may be a treatment for bleeding in high-risk surgicalExpand
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Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution.
The availability of long circulating, multifunctional polymers is critical to the development of drug delivery systems and bioconjugates. The ease of synthesis and functionalization make linearExpand
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The induction of thrombus generation on nanostructured neutral polymer brush surfaces.
Surface induced thrombus generation is a major clinical concern associated with vascular medical devices and implants. Here, we show that high graft density hydrophilic non-charged polyExpand
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Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators.
Herein we report the synthesis of biodegradable hyperbranched polyglycerols (BHPGs) having acid-cleavable core structure by anionic ring-opening multibranching polymerization (ROMBP) of glycidolExpand
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Carbohydrate structure dependent hemocompatibility of biomimetic functional polymer brushes on surfaces.
Glycocalyx mimicking glycopolymer brushes presenting mannose, galactose and glucose residues in the pyranose form, similar to those present on cell surfaces, were synthesized on planar substrates (SiExpand
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Microscale failure mechanisms leading to internal short circuit in Li-ion batteries under complex loading scenarios
One of the least understood mechanisms of Li-ion batteries is the development of internal short circuits under mechanical loads. In this study, a micro mechanical model is developed and subjected toExpand
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